2012 - Anti-Aging and Psychopharmacology Notes



June 22 2012

Current supplement regimen:


PQQ (pyrroloquinoline quinone) 50mg's/day
Aniracetam 750 mg each /4X/day
Centrophenoxine 500 mg 4/day x 4 days on, 4 days off
Acetyl-L-Carnitine 500 mg / 3 - 4 per day (high dose)
DMAE Bitartrate 150 mg / 3 per day
Alpha GPC 300 mg each / 2 per day
Omega-3 EPA/DHA  2x day http://j.mp/yoYGvO
http://j.mp/slash-risk-of-premature-death-85-percent
5-MTHF 50mg / 1X day
Pyritinol 400 mg each / 1 per day
CDP Choline 250 mg / 2 per day
Idebenone 180mg  / 1 - 2 per day
Life Extension Super Ginkgo 120mg / 2 day
Ubiquinol
Benfotiamine
Rhodiola
Phosphatidylserine  http://j.mp/zGl4hK
S-adenosylmethionine http://j.mp/Aisb71



Supplements I'm presently investigating:

Actovegin
Uncaria Tomentosa
Alpha GPC (L-alphaglycerylphosphorylcholine) – 120 mg
Huperzia Serrata - 20mg
Vinpocetine — 5mg
Bacopa (20% Bacosides) — 500 mg
Pterostilbene — 250 mcg
Mucuna Pruriens (50% l-Dopa) — 200mg
GABA — 300mg
Oat Straw (10:1) — 300 mg
Vitamin B6 – 15 mg Pyridoxine

Alpha GPC (L-alphaglycerylphosphorylcholine) – 120 mg Derived originally from lecithin, Glyceryl Phosphoryl Choline is a phospholipid metabolite found concentrated in neuronal membranes. Unlike less expensive forms of choline such as choline bitrartate, Alpha GPC has been shown to be well absorbed, easily crossing the blood brain barrier. Once delivered it helps support brain function and learning processes by directly increasing the synthesis and secretion of acetylcholine. Strong acetylcholine has been linked to memory, focus, mental drive, REM sleep states, and the prevention of mental degradation with advancing age.

Huperzine A – 100 mcg + Huperzia Serrata - 20mg (.5% Huperzine A) An extract from the plant commonly known as Northern Firmoss (Huperzia Serrata), Huperzine A is one of the most effective naturally derived acetylcholinesterase inhibitors. Huperzine A has been tested in a variety of clinical applications and shown to have positive effects on brain function.  Acetylcholinesterase (AchE) is responsible for the breakdown of Acetylcholine, and so by inhibiting AchE, more acetylcholine is available to the brain.  Efficacy has been shown in a range of 200-400 mcg daily, and safety demonstrated in trials up to 5 weeks and 600 mcg daily.

Vinpocetine — 5mg A semi-synthetic compound derived originally from the periwinkle plant, vinpocetine helps the body deliver oxygen to the brain by increasing circulation and blood flow. Extensively studied in Europe, clinical investigations have found it to provide several advantages for the human brain, including memory enhancement, increased cognitive performance, improved cerebral circulation and higher mental acuity and awareness.

AC-11® – 350mg AC-11® the proprietary compound licensed under agreement from Optigenex Inc, is derived from Uncaria Tomentosa (which is simply another name for "Cats Claw", sold at most nutrition stores and even large grocery stores), a plant indigenous to the South American rainforest. In a series of peer reviewed scientific and clinical studies conducted by third party laboratories and university medical centers, AC-11® has been shown to help the body’s natural ability to repair DNA.

Although the exact mechanisms of action are being further investigated, the scientists believe that when the body is subjected to stress affecting the integrity of the DNA, AC-11® helps activate enzymes that are instrumental in the repair processes. This goes beyond other nutritional supplement by protecting the body from damage to its fundamental building blocks: The DNA itself.

Optigenex Inc is the exclusive patent holder for AC-11®. US patent numbers: 6039949, 6238675 B1, 6361805 B2

Bacopa (20% Bacosides) — 500 mg Bacopa monnieri is an Ayurvedic herb found in the marshlands of India known to enhance clear thinking and support memory function. Ayurvedic masters have touted its cognitive enhancing effects for centuries as Bacopa has been served to Raj’s and peasants alike.

Clinical investigations show that it has strong antioxidant properties, and may protect mental function in certain adults, while animal models have shown unequivocally that bacopa improves learning skills. Bacosides, the active compounds in Bacopa, play a protective role in the synaptic functions of the nerves in the hippocampus, the seat of memory. Inside the hippocampus nerve impulses are transmitted across the synapses and bacopa is believed to help the body prevent the degeneration that impairs memory and cognition.

Pterostilbene — 250 mcg One of the hottest extracts in the field of nootropics, pterostilbene is quickly surpassing its cousin resveratrol in popularity. A natural antioxidant abundant in blueberries, anecdotal evidence suggests that this particular antioxidant is effective in eliminating free radicals that contribute to ‘mental fog’. Combined with the other antioxidants in the formula, this adds further well rounded protection and health benefits to Alpha Brain™.

Mucuna Pruriens (50% l-Dopa) — 200mg Mucuna pruriens, commonly known as velvet bean or cowhage is another Ayurvedic herb with a long history of traditional use for benefitting the brain. As science later discovered, mucuna is one of the few plants to contain high quantities of l-Dopa, a precursor to the neurotransmitter dopamine. L-dopa crosses the blood brain barrier and converts into dopamine, an important brain chemical involved in mood, sexuality, and movement. Mucuna pruriens also has antioxidant properties and is currently being studied in conjunction with the prevention/treatment of many brain conditions.

GABA — 300mg GABA or gamma-aminobutyric acid, discovered in 1950, is the most important and widespread inhibitory neurotransmitter in the brain. Symptoms of unbalanced excitation in the brain includes restlessness, irritability, and insomnia. By inhibiting excessive excitability GABA is able to help the body induce relaxation, analgesia, and even aid in sleep. In the Alpha Brain™formula, GABA plays an important role in balancing out the brain, and ensuring that the mind stays calm even as the ‘engines’ are roaring.

Oat Straw (10:1) — 300 mg Oat straw is one of nature's most powerful anti-stress nutrients and has been prescribed for of a wide range of nervous conditions. It has also been shown to help with exhaustion related neurological pains and is commonly given as a natural alternative to help combat challenges with attention span. Our formulation is extremely powerful, in a 10:1 concentration, and assists in makingAlpha Brain™ a balanced nootropic.

Vitamin B6 – 15 mg Pyridoxine (Vitamin B6) is one of the body’s busiest vitamins, involved in an estimated 101 chemical reactions. One of its primary tasks is to aid in the manufacturing of amino acids and neurotransmitters. Some of these neurotransmitters are serotonin, norepinephrine, dopamine and GABA.

Semax is a neuropeptide developed from a short 
fragment of ACTH, Pro8-Gly9-Pro10 ACTH(4-10) and is a neuroactive peptide with unique neuroregulatory properties.
Semax is a revolutionary addition to the arsenal of the Medical profession in combatting the disastrous effects of ischemic insults on the brain like the ones caused by Brain Stroke and closed head injuries.

Semax administration allows significant increases in salvaging neurons, reducing the size of infarcts and permanent damage.

Semax aids recovery and restitution of mental and motoric capacities after ischemic insults, improving the patient’s quality of life after the insult.
Semax also influences the intellectual capacities and memory as well as concentration of normal, healthy persons subjected to stressful working conditions, increasing their mental capacities and diminishing the index of workload.

Semax IS A NEUROREGULATOR, NEUROMODULATOR AND NEUROPROTECTOR

Semax IS A REVOLUTIONARY CEREBRAL REVITALISATOR

BIOLOGICAL EFFECTS OF Semax

 in the brain:

Semax induces conformation changes in receptors of neurons comprising the Limbic Reticular complex leading to the increased generation of cAMP, c-GMP as well as of eicosanoids and certain oligopeptides: somatostatin, thyroliberin factor, cholecystokinin, dopamine, acetylcholine, serotonine, adenosine and histamine. 
Semax regulates the activating and inhibitory biosubstrate relation, NMDA receptors (glutamate, aspartate, glycine, taurine) in the central and peripheral nervous system, enhances the restitution of disturbed energy metabolism of neurons and their adjacent environment, returns the disarranged relation of neuron-astroglia function to normal, augments the activation of apoptosis inhibition, stimulates the modulation of synthesis of neurotrophins, proteins and other biosubstrates for the impaired neuron’s protection.

Semax increases mRNA for NGF by 500% and for BDNF by 800%

Semax inhibits the excessive generation of Nitic Oxide caused by cerebral ischemia.

Semax increases the level of anti-inflammatory cytokines like IL-10, TGF-1ß and lowers the level of pro-inflammatory cytokines like IL-8 and C-Reactive Protein

Semax intensifies the expression of early genes that regulate and activate the adaptation process of the impaired neurons, it augments the activation of apoptosis inhibition by increasing levels of Bcl-2.


Vassopressin

Cerebrolysin

Phenotropil supposedly works wonders when taken with Semax.

N-PEP-12(MemoProve) which is a derivative of Cerebrolysin

Consider stacking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked.

Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

Stimulant X

Thermolife Stizm. WOW. this is my all time fave

XCeed is a CEE with some other boosters

Cordygen5 and Citruvol may be a great combination. It would help improve endurance, strength, oxygen utilization, ATP production, recovery, etc. In turn, it could make for an easier work day

Roxindole

Phenylpiracetam

Carphedon or Phenotropil

But the other day a friend found a website selling phenylpiracetam. This is more well known as 'Carphedon' or 'Phenotropil' - an obscure Russian stimulant developed to keep astronauts awake on long missions, and occasionally used in Russia as a prescription nootropic for various types of neurological disease. It became well known a couple years ago when a bunch of athletes got kicked out of the Olympics for using it, leading a nootropic supplier in California to start selling it on the Internet as a supplement.

"Antidepressant" and "euphoriant" are distinct, and we have various classes of drugs that can select pretty effectively either one or the other effect.  There are also certain classes of drugs which may produce both a euphoric and an antidepressant effect, for example: Nardil, Parnate, Amineptine, Ketamine, Cannabinoids, and the endorphin release triggered by opiates etc.

Furazabol
Furazabol is for cutting, vascularity, weight, cholesterol improvement:  However, recently 100 mg/mL versions have become available. A common dosage can be 10–25 mg/day orally and 25–50 mg daily injected, with optimal results usually seen at 50 mg/day.

Cimaterol
The best choice for weight control and even fat-burning appears to be Cimaterol.  Investigate further.

Pretreatment with all CCBs significantly enhanced the analgesic effect of morphine in both tests of nociception. Further, concomitant administration of one of the CCBs, diltiazem with morphine prevented the development of tolerance to the latter. However, combination of diltiazem with morphine, like morphine alone was found to be ineffective in morphine tolerant animals. Results, thus, show that CCBs produced an analgesic effect of their own in formalin-induced tonic pain and potentiated the analgesic activity of morphine. They also modulated opioid-induced tolerance.




ANTI AGING DOCTOR LIST BELOW:

Interesting pharma or RC ("research chemical"):

Prolintane aka Catovit

1-(thien-2-yl)isopropylamine

Butylone


Interesting Nootropic: Rolipram (http://j.mp/rolipram)

CX717
“It generates a state of cortical wakefulness without stimulation,” says Gary Lynch at the University of California at Irvine, who invented ampakines. Cortex Pharmaceuticals Inc., based in Irvine, California

Ampakines work by binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. And because of their short half-life - hours in this case - ampakines have few side effects.

Rasagiline & Selegiline By inhibiting MAO-B, rasagiline prevents the deamination of the monoamines dopamine and phenethylamine (PEA), thereby increasing their concentration in the synapse and curbing production of the reactive oxygen species, hydrogen peroxide. High concentrations of hydrogen peroxide are associated with increased oxidative stress. Rasagiline both raises levels of striatal dopamine produced from levodopa and improves the survival prospects of ailing dopaminergic neurons themselves. This salvage job helps restore a measure of normal locomotion, gait and coordination in Parkinsonian patients while delaying their physical decline.

Both selegiline and rasagiline are neuroprotective via multiple mechanisms that are poorly understood. However, their role in stabilising mitochondrial membrane potential is critical. The propargylamine moiety rather than MAO inhibition per se apparently holds the key to their neuroprotective action: the S isomer of rasagiline is some 1000 times less potent as an MAO inhibitor, but it's still protective against neurotoxic insults. Rasagiline inhibits activation of the apoptotic cascade triggered by dopamine neurotoxins and oxidative stress. Apoptosis is an active process of programmed cell-death induced by exposure to neurotoxins. Rasagiline and other propargylamines can rescue deteriorating dopaminergic neurons by inhibiting the "death signal" transduction-mechanism of mitochondrial permeability transition. Current evidence suggests that rasagiline may be more effective than selegiline in salvaging dopamine nerve cells from the usual neurological carnage of later life.


Two fascinating Russian chems and experience reports:

Cerebrolysin It's the second day I take cerebrolysin only. The effect is very interesting, I wake up very energetic, my sensitivity to caffeine has increased a lot. A cup of espresso is too much for me.

Cerebrolysin appears to have some kind of antidepressant / anti-anxiety effect. I have never used anxiolytics or antidepressants before but I noticed that I don't feel depressed or anxious under extremely stressful situations. I had trouble getting asleep as well, but now I just go to my bed and I get asleep in 10-15 mins.

Cerebrolysin probably does not have a typical antidepressant / anxiolytic affect. I guess that you can only notice the effect of cerebrolysin if you have to undergo extremely high workload, stressful situations... I simply don't get tired and I can relax much easier after any stressful event

This nootropic is one of those which have a very pronounced effect and it scares me  To be honest, it is one of the reasons I will not continue taking cerebrolysin. Nobody knows what are the long term effects of this drug. I am a healthy individual, so I don't see any need to take a risk and use it any longer. However it was a positive experience


Phenotropil works wonders when I take it with Semax.

The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"

It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.

Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.

As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.

I hope this is useful to everyone interested in this peptide.


Fascinating Nootropic and notes + list:

Noopept.

1010pharma.com is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax right now, anti-aging.com may carry...

One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

http://www.apteka-dr...erc-3ml-n1.aspx

phenylpiracetam

http://www.backtone.com/

N-PEP-12(MemoProve) which is a derivative of Cerebrolysin

Memantine - Namenda

Alpha GPC

Selegiline - Deprenyl

Horny goat weed - Same as above. PDE5 inhibition could be helpful as well on occasion (those first couple hours of amphetamine are brutal).

Agmatine - It's an obscure possible neurotransmitter produced from arginine that among many possible benefits blocks NMDA receptors and thus hopefully helps mitigate amphetamine tolerance. It may improve mood, memory, and sleep as well.

Phenibut, while I loved the initial effects, became detrimental VERY FAST (depressant action). So 2-3 times a week seems too much to me. Just be aware of this.

Huperzine A - NMDA. Hopefully some memory improvement. I've read that this may be dangerous to take regularly so I will probably go with 200mcg every other day. If taking any of these drugs for depression, be very careful with Huperzine A.

Green tea extract - It's high in ECGC. Good anti-oxidant. I will likely take this daily.

Bacopa - I took it regularly for about three weeks, one dose in the evening. It can make you a bit drowsy.

Magnesium Glycinate - best form of magnesium to take.

L-Theanine - Fantastic DA augmentor.

Sulbutiamine 300mg -Sulbutiamine is a funny substance. It's amazing at first. Many have noticed it decreases creativity to an extent, which I would tend to agree with. But it should also be used very sparingly-- tolerance will develop. Because of the receptors it antagonizes/agonizes, its effects are much more pronounced with caffeine. I.e., it is synergistic.

Interesting nutra to consider taking or taking more regularly: DL-Phenylalanine Yohimbe
L-Tyrosine Copper Gluconate Choline Bitartrate Dicalcium Phosphate 120 MG L-Potassium Aspartate 30 MG Propionyl-L-Carnitine 1000 MG L-Asparagine 650 MG Acetyl-L-Carnitine 500 MG L-Potassium Aspartate 150 MG Caffeine (USP) 125 MG L-Tyrosine: 1800mg Acetyl L-Carnitine: 500mg Sulbutiamine: 300mg Rhodiola Rosea: 200mg -(standardized to 3%) Vinpocetine: 20mg Pyrodoxine HCL: 8mg

Camellia Sinensis 60% Polyphenols (green leaves), Yohimbine Alkaloids (pausinystalia yohimbe bark), 6’ 7’-Dihydroxybergamottin (fruit), Camellia Sinensis 60% Polyphenols (white leaves), Capsaicin (fruit)

Stimulant X www.stimulantx.com

Most frequently prescribed MAOIs include Nardil, Parnate, and Elderpril.

Nicotinic analogues

Gotu Kola - claim that oldest man who ever lived (chinese dude claimed to be over 200 years old) was taking tons of this stuff.

Take CEE and some adaptogens

AMP or Focus XT for a neural boost

Panax ginseng

Palatinose + extra citrulline malate + extra beta alanine + ALCAR + Tyrosine synergy

Maca - traded as currency amongst spanish colonials once

Ergopharm's amp...stimx, pumpjuice2.0 (not just a stim).

Glucuronolactone

XCeed is a CEE

Yerba mate

PW could definitely help out. Cordygen5 and Citruvo: Improves endurance, strength, oxygen efficiency, ATP production

Thermolife Stizm. WOW excellent reviews

Metformin
The mechanisms for lifespan extension by metformin are not completely understood yet but probably involve AMPK and its downstream target mTOR (fig. 1) (4). mTOR is also the target of the famous life extension drug rapamycin that increases lifespan in mice both when administered early and during middle life (15,16). mTOR inhibits autophagy thus metformin activates autophagy by inhibiting mTOR. Autophagy clears cells from dysfunctional organelles – such as mitochondria – and other junk that can impair normal cellular functions and thereby extends lifespan. mTOR stimulates protein synthesis and for still very incomplete understood reasons protein synthesis reduces lifespan. Therefore again metformin is expected to retard aging. If the cell cycle is arrested – that is the cell temporally stops dividing – and the cell continues to receive growth signals (mTOR stays active), it can lead to cell senescence – a state of permanent cell cycle arrest (4). Senescent cells secrete proinflammatory molecules, this has been termed the senescence-associated secretory phenotype, and can locally stimulate tumor growth (17). Metformin is expected to prevent cell senescence by removing the growth signal pressure. AMPK inhibits NAD(P)H oxidase, an enzyme whose action produces superoxide – a free radical. Metformin thus decreases free radical production (4). Free radicals are molecules that have an unpaired electron, they desperately try to find an extra electron to stabilize their configuration and in the process destroy other molecules by stealing their electrons. The free radical theory of aging is without doubt the most well known mechanistic aging theory. It was first proposed by Denham Harman in 1956 (18). Since then the failure of antioxidants to extend the lifespan has cast doubt on the validity of the free radical theory but still most biogerontologists think that free radicals do play a certain role. In fact some even suggest that the failure of antioxidants is expected because they undermine the bodies stress response (19). AMPK can be activated by: (i) binding of AMP, and (ii) phosphorylation by other enzymes. Metformin has clearly been shown to increase the phosphorylation of AMPK but the effects on AMP are disputed. Phenformin and buformin inhibits complex I of the respiratory chain, so maybe metformin does so too. Such an inhibition would decrease ATP – the universal energy currency for life – production and thereby increase AMP levels.

Phenylpiracetam, Phenotropil, Fenotropil, Carphedon

Fenotropil has a positive effect on metabolism and blood circulation within the brain. It stimulates the Redox processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in Ischemic areas of the brain. Moreover, it increases noradrenaline, dopamine, and serotonin brain levels. It does not affect GABA levels and is not associated with GABA A- and -B receptors. It produces no significant effect on spontaneous brain activity.

Fenotropil has no effect on the respiratory and cardiovascular systems. However, it produces a mild diuretic effect and anorexic activity in the exchange application.

Fenotropil provides a moderately stimulating effect on motor responses and improves physical performance. The moderate awareness-inducing effect of the drug is combined with anxiolytic activity. Fenotropil improves mood and has analgesic effects, increasing the pain threshold. Additionally, it has an adaptogenic effect, increasing the organism's resistance to stress in conditions of increased mental and physical stress and fatigue. Furthermore, it increases resistance to freezing hypokinesia.

With the advent of Phenotropil, marked improvements were noted in vision (an increase in sharpness, brightness, and field of view). Fenotropil improves blood flow to the lower extremities. Fenotropil stimulates the production of antibodies in response to the antigen, indicating that it has immunostimulator properties but at the same time does not cause the development of immediate hypersensitivity reactions and does not alter the allergic inflammatory reaction of the skin caused by the introduction of foreign proteins. In the exchange application, Phenotropil does not develop drug dependence and tolerance. The drug is not marked in the development of withdrawal syndrome.

Actions of Fenotropil are seen after a single application, which is important when the drug is used in extreme conditions. Phenotropil significantly enhances the action of other Nootropic drugs.

Fenotropil is not metabolized in the body and excreted, unchanged in form. About 40% is excreted in the urine and 60% in bile and sweat. The half-life is 3-5 hours. The average single dose is 150 mg (100-250 mg); the average daily dose is 250 mg (200-300 mg). The maximum daily dose is 750 mg. The multiplicity of reception is 1-2 times a day. A daily dose of 100 mg can be taken one time a day (morning), while doses exceeding 100 mg should be taken in two doses. The duration of treatment ranges from two weeks to three months. The average course of treatment is 30 days.



RECREATIONAL SUBSTANCES WORTH RESEARCHING:

Dimoxamine

DOM

2C-I

2C-I and 2-CT-2

2C-I (2,5-dimethoxy-4-iodophenethylamine) Most likely candidate for the coveted title "the next ecstasy".

http://medi.ru/doc/3101.htm http://www.phenotropil.ru/pub/ kunwha.com


Cerebrolysin has to be injected intravenously or intramuscularly. It cannot be injected into the fatty tissue. An intramuscular (IM) injection is a shot where the needle goes into the muscle layer under the skin to deliver medicine. IM injections are deeper than subcutaneous injections (given under the skin). Parts of the Body Involved - Upper arm, Top of the thigh, Buttocks (most common and recommended for 5 ml cerebrolysin injections).

A needle passes through skin and fat layers into the muscle fibers to deliver medicine.

http://www.longecity.org/forum/topic/28171-cerebrolysin/


NOTES:

I have a few questions if you wouldn't mind answering them?

1) How long did you use it for? I beleive there's five 5 ml ampoules in each packet. It sounds like you took 5 ml (first day), 5 ml (2nd day), 10 ml (3rd day), then possibly 5 ml the 5th day if you used all the ampoules up?

2) Dosaging Instructions According to Antiaging-Systems: The normal dosage pattern seems to be to do an injection 5 days out of a 7 day week for 4 weeks. Alzheimers patients (or possibly certain people suffering a delay of some sort to a lesser severity) would take 1 ml, 5 ml, or 10 ml ampoules once a day Mon.-Fri. (or whatever's 5 days; skipping 2 days each week) for 4 weeks (before waiting 3 months to begin again). The benefits are supposed to last possibly up to 3-6 months.

With that being said, 10 ml seems like it could potentially be a bit much for a healthy person to take. Did you notice a direct difference between the 5 ml on the 1st day vs. the last day? Or the 5 ml (from the 1st and last day) vs. the 10 ml?

3) Any dizziness, headache, or heat sensations? According to http://www.antiaging...erebrolysin.htm these are some rarer side-effects that may occur if administered too quickly? (meaning possibly jumping right up to 10 ml could of been done too quickly?)

4) It doesn't appear side-effects are common. Perhaps a healthy person could order 10 1 ml ampoules (this is much cheaper for around $50) instead of the 5 5ml (around $70) or 5 10ml (around $90). This would mean for $100 someone could do the 4 week program using only 1 ml ampoules instead of paying around $280 for a 4 week program using 5 ml ampoules.

5) I don't want to throw this thread off track here but have you heard of "Cortexinum"?http://www.pharmacy1...age.asp?id=1375 It seems surprisingly similar to Cerebrolysin. I'm wondering if this is some sort of Russian variant brand of Cerebrolysin?


I will post this again:

There are no Cerebrolysin alternatives which can be taken orally except N-PEP-12(MemoProve) which is a derivative of Cerebrolysin and it is much less potent.

Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com


1) I had 2 packs of cerebrolysin. I used 5 ml for the first 3 days and 10 for ml for 2 days.

2) I did not notice anything for the first 2 days. The effect became really noticeable on the 3rd day, even more noticeable on 4th and 5th. Btw, 1 ml ampules are usually given to kids.

3) I did not feel any dizziness, headache, or heat sensations. Those side effects usually occur when you inject a cold liquid intravenously. To avoid this it has to be warm enough (room temperature) and you have to inject it slowly.

4) 1 ml is a very small dose, it is not enough even for a healthy adult. I have read the instructions and it says that doses of 1-2 ml are given to kids. Doses up to 50 ml (IV) can be given in severe cases. Cerebrolysin is overpriced if you buy it online. I bought another pack of cerebrolysin while traveling in one of the EU countries, the price at the pharmacy was 34 USD (5 x 5ml amp)

5) If I remember correctly cortexin is made from cattle brain. I will try to get some more info about it. Edited by anony4mous, 22 April 2009 - 01:32 AM.



Cortexin peptide drug is largely similar to the cerebrolysin, used also by intramuscular injection./Pharmacological Effects: The drug improves cerebral metabolism. Cortexin represents liofilizat obtained by acetate extract from the bark of the brain of cattle or pigs, which contains low-molecular active neuropeptides, the molecular weight of not more than 10 000 dalton, sufficient to penetrate through hematoencephalic barrier./Cortexin has a unique multi-effects on the brain, as demonstrated in metabolic regulation, neuropatronage, functional neuromodulation, neurotrophic activity. Cortexin improves the efficiency of energy metabolism of brain cells, improves the intracellular synthesis of protein, regulates the processes of oxidation of lipids in cells of the brain reduces the formation of free radicals, blocking the processes of free-radical oxidation. The product eliminates the imbalance of braking and excitatory amino acids, has a moderate GABA-ergic action./The drug has a positive effect in violation of cognitive function, improves concentration, short-term memory, learning ability, accelerates the recovery of the functions of the brain after stress effects, regulates the levels of serotonin and dopamine. It stimulates the process of mental activity, not providing excessive activation of influence, restores bioelectric activity of the brain, stimulates the reparative processes in the brain./Indications for use: Violations of the cerebral circulation; encephalopathy of different genesis, acute and chronic encephalitis and encephalomyelitis, epilepsy, brain trauma, viral and bacterial neuroinfection; infantile cerebral palsy, delayed psychomotor and speech development in children; asthenia, memory, thinking, reducing the ability to learn.


Concentrate always means - impure. Hydrolyate means a more exact synthesis of adding hydrogen to the the purified mix. Both kinda suck, because all you want is the chemical, but what the process gives you, is impurities. The more you get rid of that - the higher the costs get.

I was taking up to 10 ml of cerebrolysine daily at work though I/M injections, easily for a good 6 months if not more. (Usually in 2 injections, although I've shot 10ml straight up before in one large syringe) Since I worked in 4-day shifts, I'd usually go 4 days on and then 4 days off to cool off my neurons  That easily allowed me to handle all the stresses, and I was one of the best at that particular job. Despite having abused illegal drugs in the past and being a frequent cannabis smoker, I experienced little to no "stoner burnout" and was able to concentrate and perform tasks faster than most of my colleagues at the same experience level. After a long 12-hour work day, after which a normal brain turns to mush, I was still fresh and eager to go out with friends/ see girls etc, while otherwise I'd be drained and only wanting to sleep.


So instead of rambling on further, let me just break down some effects and side-effects, short and long term:

-This stuff has a MARKED anti-depressant effect. You basically feel like back in the happiest moments of your childhood. Everyone has had one of those days when they're just "on fire" and "on top of the game". With Cerebrolysine, pretty much every day is like that - you're not overly happy or vegetated like off standard anti-depressants, but you're "on point" at whatever you do. Stuff like your subconscious and conscious fears all go right out of the window, and it has a bit of a socially-inhibiting effect too.

-If you thought weed gets you the munchies, wait till you try this stuff. When you first start on this cycle, you get hungry as a SAVAGE. I usually eat just enough to be full, not overly gorged, but this stuff had me tearing up huge meals and not even feeling incapacitated by everything I just ate. I'd attribute this to the fact that with all the additional peptides and stuff, your body needs more nutrition. Sort of like adding B-vitamins to stuff like Pyritinol or even good old 5-HTP.

-Cerebrolysine helps alleviate most, if not all symptoms of post-intoxication syndrome for illicit drugs. I once gave my friend a shot after his most recent cocaine binge and he turned from a pale shadow who was about to pass out back to his normal self - energetic, enthusiastic, and motivated. Plus his foul mood and edginess were completely gone. It also seems to ease the alcohol-related hangover better than some other substances (although many nootropics are much better for that IMO since they're GABA-active). My other friend also liked taking it as a "corrector agent" for other nootropics/supplements, claiming it helped alleviate certain unwanted effects of piracetam, while preventing one from overloading on one particular amino acid too much. I personally avoid ALL other substances when doing cerebrolysine. It simply overshadows them all for me.

-They definitely put some kind of a painkiller in there. Shooting cortexin (which is similar, but I like it alot less, as it "vegetates" and sedates me too much to where I'm more mentally capable, but simply don't care) without a novacaine solution is literally a huge pain in the rear, while shooting straight cerebrolysine into my tiny tricep with a huge needle made my whole arm go numb for a short time, like an anastetic would.

-I've measured my blood pressure several times before and after the injections, and there is a slight blood pressure elevation. If you inject too fast, the heart rate jumps and you may sweat profusely. However it gives you a nice sort of a "rush" to where you feel very relaxed, but not incapacitated or drugged by any stretch of imagination. The headaches are there, but are very slight, and usually start about 2-3 hours after the injection.

-The long-term effects aren't so pleasant. There is an increasing feeling of "mounting personal hell" as I like to call it. Basically, all the negative traits of one's character seem to be unnaturally emphasized and underlined in your mind, while the positives seem little and insignificant. It doesn't really manifest itself in a severe form to others, but you may feel "grumpy" and "dissatisfied" even when you seem to be razor-sharp mentally. A good comparision would be some rich spoiled kid who has everything throwing tantrums and breaking stuff, just because he is rich and spoiled. Several of my friends reported very similar mental side effects. This is what initially led me to stop taking it by "tapering down" (I don't think it's a good method by the way, but since I was doin it daily for a while I decided for a slower descent). A .5 ml less every day for several days, then a week at 1ml and then 0.5 and then you're shooting colored water for placebo effects

- Some people report a HUGE boost in their sexual activity. I noticed only a slight boost

- When you're off the cerebrolysine, you feel like it's a bad day for no reason (see above having a top of your game day for no reason lol). I didn't notice any significant negative long-term effects on my cognitive processes. On the contrary I seem to be able to concentrate better at any time, without taking any substances, or even after smoking a lot of weed. I'm now able to "zone in" on something more completely and do better at focusing.

-This stuff has very strong and powerful overall effects, it is the most effective out of injectable nootropics/smart drugs that I've tried. Cortexin doesn't even come close, and various Cerebrolysine derivatives (we ahve a Cerebrolysate here) are nothin more than cheap imitations.

I've decided for another mini-cycle just now, about 3 years after that last lengthy episode. I'm sticking to what the doctors here recommend: 5ml every OTHER day. Seems to be the correct dosage and schedule.

I hope it doesn't sound too much like promo for the Austrian pharmaceuticals company which makes this stuff. It's really not somethin you want to mess around with if you don't know what you're doing.

http://www.longecity.org/forum/topic/28171-cerebrolysin/page__st__30



FASCINATING INFO ON AGING:

THE FOUR CRIMINALS BEHIND AGING: 1. Methylation 2. Oxidation 3. Glycation 4. Inflammation


Glycation, Methylation, Inflammation, Oxidation


Glycation is a chemical process that takes places in the body, which binds sugar and proteins. This binding with sugar makes the structural proteins in your body stiffer and contributes to accelerated aging by reducing flexibility of tissues and organs.

The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases.[8] AGEs have been implicated in Alzheimer's Disease,[9] cardiovascular disease,[10] and stroke.[11] The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis. They form photosensitizers in the crystalline lens, which has implications for cataract development.  Reduced muscle function is also associated with AGEs.

It is not yet clear whether glycation can actually be reversed, however research is currently being conducted on a class of chemicals called AGE breakers. These drugs would theoretically “undo” the damage in glycated tissues, returning them to their normal state.

For all the promise of youth-restoring remedies none has ever reversed the process of aging. Now, for the first time, researchers at Alteon Inc. (alteonpharma.com) have developed a drug that rejuvenates hearts and blood vessels, stiffened with age, by breaking up molecules that cause the trouble.

Anti AGEs

Elusive alt-711 (alagebrium)

Aminoguanidine

NtBHA (Geronova)

N-acetyl-L-carnosine (NALC) (Superior Nutraceuticals)



OTHER NOTES: MDD

Quercetin

Fisetin

Similar to many other flavonoids such as the structurally related flavonol quercetin, fisetin is a potent antioxidant. Its antioxidative activity may be due to its structural properties as well as to its ability to modulate certain cellular signaling pathways, especially protein kinase and lipid kinase pathways. For example, fisetin has been shown to induce the transcription factor Nrf2, leading to increased expression of several protective and antioxidative genes. One study at the Salk Institute found that fisetin may help improve memory and protect the brain from the onset of Alzheimer's disease and also that it may be useful for reducing kidney failure in diabetics.

Side effects Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor. This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.  Fisetin among other flavonoids is suspected to increase risk of infant leukemia (which is rare disease).


Rapamycin
Rapamycin was first shown to extend lifespan in eukaryotes in 2006. Powers et al. showed a dose-responsive effect of rapamycin on lifespan extension in yeast cells. Building on this and other work, in a 2009 study, the lifespans of mice fed rapamycin were increased between 28% and 38% from the beginning of treatment, or 9% to 14% in total increased maximum lifespan. Of particular note, the treatment began in mice aged 20 months, the equivalent of 60 human years. This suggests the possibility of an effective antiaging treatment for humans at an already-advanced age, as opposed to requiring a lifelong regimen beginning in youth. Because it strongly suppresses the immune system, though, people taking rapamycin are more susceptible to dangerous infections. It is not known whether rapamycin will have similar lifespan-lengthening effects in humans, and study authors caution the drug should not be used by the general population for this use until more is known about the substance.

Omega-3 EPA/DHA  http://j.mp/yoYGvO

Furazabol
Furazabol is for cutting, vascularity, weight, cholesterol improvement:  However, recently 100 mg/mL versions have become available. A common dosage can be 10–25 mg/day orally and 25–50 mg daily injected, with optimal results usually seen at 50 mg/day.

Cimaterol
The best choice for weight control and even fat-burning appears to be Cimaterol.  Investigate further.

L-tartrate

Cytomel
There are many advantages to using Cytomel to optimize our metabolic rate. It will also increase your bodys ability to synthesize protein, but from what Ive seen personally, it acts as a catabolic when it isn't administered with anabolic steroids. It is often the last thing added into a pre bodybuilding contest diet as it has a reputation for getting rid of the last few percentages of bodyfat& the "sticky fat" as its called in bodybuilding, the fat that just doesnt want to leave you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a diet to lose fat, as it will optimize your metabolic rate, which should be done at the outset of a diet, not after the calorie restriction has diminished your thyroid output and you are adding it in simply to replace what was lost. Read more: http://www.steroid.com/Cytomel.php#ixzz1iwD2YLl4

Clenbuterol Most users experience a very strong energy rush within 15 minutes of each dose. This characteristic makes it a popular pre-workout intensity pill and thermogenic.  Approximately 8% of users experience a paradoxical effect and become a bit lethargic.

Galantamine used with choline bitartrate or Alpha-GPC Galantamine has been used as a neuroprotectant and sleep aid, Galantamine can help people fall asleep and also increase sleep-stage quality.

7-amino-8-hydroxbutyric acid (GABOB) worth researching for sleep and anxiolytic.

chocamine+deprenyl+inositol+bacopa+sam-E interesting combination for cognitive enhancement.  Another would be 1 gram of L-theanine, 1 gram of Green Tea, Fish Oil, and two amp.

Ma-huang (oral) and or Sida cordifolia (oral) / Or ephedrine HCL

(K)-R-ALA (oral)

XCeed is a CEE with some other boosters

Try Yerba Mate wisdom of the ancients vanilla / and guayaki's

Cordygen5 and Citruvol may be a great combination


Interesting understanding:

Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

"Antidepressant" and "euphoriant" are distinct, and we have various classes of drugs that can select pretty effectively either one or the other effect.  There are also certain classes of drugs which may produce both a euphoric and an antidepressant effect, for example: Nardil, Parnate, Amineptine, Ketamine, Cannabinoids, and the endorphin release triggered by opiates etc.

Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats. http://www.ncbi.nlm.nih.gov/pubmed/22135908

Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Finally, increasing CREB expression after withdrawal from self-administration enhanced cocaine-primed relapse, while reducing CREB levels facilitated extinction of cocaine seeking, but neither altered relapse induced by cocaine cues or footshock stress.

Dopamine types: D1 dysphoric D2 euphoric

What I've read about Memantine on a large number of internet sites tells me it is believed to work by protecting nerve cells from being killed off by glutamate toxicity. This happens in Alzheimer's when a certain type of receptor on the cells, the NMDA receptor, is over-stimulated by glutamate and releases an overload of calcium into the cell, causing aptosis / excitotoxicity. Memantine regulates the calcium ion inflow by partially blocking the NMDA receptor. Although memantine is a patented prescription NMDA blocker, so too are a number of non-prescription nutriceuticals.  Among them are: Huperzine-A, which aside from its primary action as a a cholinesterase inhibitor will also protect the brain from glutamate excitotoxicity.  Theanine, is a derivative of green tea, and a potent DA producer (I do not believe this is via a conversion into L-Dopa, then Dopamine, much the way many Alzheimers drugs work, rather I think it sponsors a spike in endogenous production of the DA neurotransmitter) also.  L-theanine has a paradoxical relaxing effect and is believed to be the agent that counters the stimulating and sometimes anxiety producing effects of caffeine contained in most green teas.  L-theanine typically has anxiolytic and mood-elevating effects without drowsiness.

Vitamin E and the methylcobalamin form of B12 are effective neuroprotectants.  The Lithium info I found recently, and it is being considered for Alzheimer's trials. As it's available in safe supplement form as lithium orotate, I give her that also, (one capsule daily) and it does seem to be giving her an extra improvement in mood, and she has a good sense of humour, often with fits of giggles! I read about the effects of Lithium orotate at a number of sites. It should be stressed that this only applies to the orotate form of lithium, which is non-prescription yet still effective at stabillizing mood.

Should investigate OPCs.  Basically they're polyphenols, principally Proanthocyanidin.  The group are powerful antioxidants that have recently been stabilized and made bioavailable.

Enhancing BDNF in the NAA produces a behavioral depressant effect whereas the opposite is true to increasing BDNF in the hippocampus.

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH(2)) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)) are two recently isolated mu-opioid selective peptides with a potent antinociceptive activity, involved in a number of physiological processes, including food intake, vasomotricity, sexual behavior, as well as neuroendocrine and cardiorespiratory functions. The neuroanatomical distribution of endomorphins prompted us to study their antidepressant activity in two animal behavioral models of depression: forced-swimming and tail-suspension tests. In both tests, the intracerebroventricular (i.c.v.) injection of either endomorphin-1 or endomorphin-2 significantly decreased the duration of immobility, interpreted as an expression of 'behavioral despair', which could be related to the depression syndrome. These effects of endomorphins did not result from the stimulation of the animal motor activity. We have also demonstrated that the antidepressant-like effect of endomorphins was antagonized by the universal opioid antagonist, naloxone and the mu-opioid receptor selective antagonist, beta-funaltrexamine. In contrast, this effect was not antagonized by delta- and kappa-opioid receptor selective antagonists, naltrindole and nor-binaltorphimine, respectively. The results of the present study demonstrate that endomorphin-1 and endomorphin-2 produce potent antidepressant-like effects after i.c.v. injection in mice. We may suggest that endomorphins and the mu-opioid receptors might be involved in the physiopathology of depressive disorders, and that the endomorphinergic system could serve as a novel target for the development of antidepressant drugs.







My Current Supplement Regimen:

Pramiracetam

Hydergine

Idebenone



Considering taking:

Roxindole

Phenylpiracetam

Carphedon or Phenotropil

Adapton Iherb.com - TERRIBLE fish smell, no noticable effects after a couple of months taking it


Interesting information and posts concerning opioids and mood:

Potential iatrogenic mood and cognitive declines associated with long-acting opioid therapy were examined in 19 patients receiving long-acting oral opioid medications and compared to ten patients receiving usual care. Pain, mood, and cognitive function were measured before and after achieving stable doses. In addition to reducing pain, long-acting opioid medication reduced anxiety and hostility. No declines in cognitive function were associated with the long-acting opioid medications, and the group receiving long-acting opioid medications showed significant improvement on a measure of psychomotor speed and sustained attention. Both patient groups reported significant reductions in perceived impairment in daily activities due to pain. Treatment responders taking long-acting opioid medications (63%) were taking a significantly lower dose at follow-up than the treatment non-responder group. These findings suggest that long-acting opioid medications can improve mood and do not impair cognitive functioning.

Posts

Morphine, a mood brightening smart drug http://opioids.com/cogmood/morphine.html

Case studies, long term relief of depression in highly refractory cases with fixed doses of oxycodone. http://opioids.com/antidepressant/opiate.html

Use of opiates in highly refractory AD and ECT nonresponse. http://opioids.com/antidepressant/opiates.html

The DST and as predictor of response to opiates. http://opioids.com/antidepressant/depression-subtypes.html

Methadone and morphine in depression http://opioids.com/antidepressant/index.html

The antdepressant effect of endomorphins. http://opioids.com/endomorphins/antidepressant.html


































































ANTI AGING DOCTOR LIST BELOW:

REGIMEN:
PQQ (pyrroloquinoline quinone) 50mg's/day Aniracetam 750 mg each /4X/day Centrophenoxine 500 mg 4/day x 4 days on, 4 days off Acetyl-L-Carnitine 500 mg / 3 - 4 per day (high dose) DMAE Bitartrate 150 mg / 3 per day Alpha GPC 300 mg each / 2 per day Omega-3 EPA/DHA  2x day http://j.mp/yoYGvO http://j.mp/slash-risk-of-premature-death-85-percent 5-MTHF 50mg / 1X day Pyritinol 400 mg each / 1 per day CDP Choline 250 mg / 2 per day Idebenone 180mg  / 1 - 2 per day Life Extension Super Ginkgo 120mg / 2 day Ubiquinol Benfotiamine Rhodiola
Phosphatidylserine  http://j.mp/zGl4hK S-adenosylmethionine http://j.mp/Aisb71


Interesting pharma or RC ("research chemical"):

Prolintane aka Catovit

1-(thien-2-yl)isopropylamine

Butylone


Interesting Nootropic: Rolipram (http://j.mp/rolipram)

CX717
“It generates a state of cortical wakefulness without stimulation,” says Gary Lynch at the University of California at Irvine, who invented ampakines. Cortex Pharmaceuticals Inc., based in Irvine, California

Ampakines work by binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. And because of their short half-life - hours in this case - ampakines have few side effects.

Rasagiline & Selegiline By inhibiting MAO-B, rasagiline prevents the deamination of the monoamines dopamine and phenethylamine (PEA), thereby increasing their concentration in the synapse and curbing production of the reactive oxygen species, hydrogen peroxide. High concentrations of hydrogen peroxide are associated with increased oxidative stress. Rasagiline both raises levels of striatal dopamine produced from levodopa and improves the survival prospects of ailing dopaminergic neurons themselves. This salvage job helps restore a measure of normal locomotion, gait and coordination in Parkinsonian patients while delaying their physical decline.

Both selegiline and rasagiline are neuroprotective via multiple mechanisms that are poorly understood. However, their role in stabilising mitochondrial membrane potential is critical. The propargylamine moiety rather than MAO inhibition per se apparently holds the key to their neuroprotective action: the S isomer of rasagiline is some 1000 times less potent as an MAO inhibitor, but it's still protective against neurotoxic insults. Rasagiline inhibits activation of the apoptotic cascade triggered by dopamine neurotoxins and oxidative stress. Apoptosis is an active process of programmed cell-death induced by exposure to neurotoxins. Rasagiline and other propargylamines can rescue deteriorating dopaminergic neurons by inhibiting the "death signal" transduction-mechanism of mitochondrial permeability transition. Current evidence suggests that rasagiline may be more effective than selegiline in salvaging dopamine nerve cells from the usual neurological carnage of later life.


Two fascinating Russian chems and experience reports:

Cerebrolysin It's the second day I take cerebrolysin only. The effect is very interesting, I wake up very energetic, my sensitivity to caffeine has increased a lot. A cup of espresso is too much for me.

Cerebrolysin appears to have some kind of antidepressant / anti-anxiety effect. I have never used anxiolytics or antidepressants before but I noticed that I don't feel depressed or anxious under extremely stressful situations. I had trouble getting asleep as well, but now I just go to my bed and I get asleep in 10-15 mins.

Cerebrolysin probably does not have a typical antidepressant / anxiolytic affect. I guess that you can only notice the effect of cerebrolysin if you have to undergo extremely high workload, stressful situations... I simply don't get tired and I can relax much easier after any stressful event

This nootropic is one of those which have a very pronounced effect and it scares me  To be honest, it is one of the reasons I will not continue taking cerebrolysin. Nobody knows what are the long term effects of this drug. I am a healthy individual, so I don't see any need to take a risk and use it any longer. However it was a positive experience


Phenotropil works wonders when I take it with Semax.

The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"

It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.

Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.

As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.

I hope this is useful to everyone interested in this peptide.


Fascinating Nootropic and notes + list:

Noopept.

1010pharma.com is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax right now, anti-aging.com may carry...

One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

http://www.apteka-dr...erc-3ml-n1.aspx

phenylpiracetam

http://www.backtone.com/

N-PEP-12(MemoProve) which is a derivative of Cerebrolysin

Memantine - Namenda

Alpha GPC

Selegiline - Deprenyl

Horny goat weed - Same as above. PDE5 inhibition could be helpful as well on occasion (those first couple hours of amphetamine are brutal).

Agmatine - It's an obscure possible neurotransmitter produced from arginine that among many possible benefits blocks NMDA receptors and thus hopefully helps mitigate amphetamine tolerance. It may improve mood, memory, and sleep as well.

Phenibut, while I loved the initial effects, became detrimental VERY FAST (depressant action). So 2-3 times a week seems too much to me. Just be aware of this.

Huperzine A - NMDA. Hopefully some memory improvement. I've read that this may be dangerous to take regularly so I will probably go with 200mcg every other day. If taking any of these drugs for depression, be very careful with Huperzine A.

Green tea extract - It's high in ECGC. Good anti-oxidant. I will likely take this daily.

Bacopa - I took it regularly for about three weeks, one dose in the evening. It can make you a bit drowsy.

Magnesium Glycinate - best form of magnesium to take.

L-Theanine - Fantastic DA augmentor.

Sulbutiamine 300mg -Sulbutiamine is a funny substance. It's amazing at first. Many have noticed it decreases creativity to an extent, which I would tend to agree with. But it should also be used very sparingly-- tolerance will develop. Because of the receptors it antagonizes/agonizes, its effects are much more pronounced with caffeine. I.e., it is synergistic.

Interesting nutra to consider taking or taking more regularly: DL-Phenylalanine Yohimbe
L-Tyrosine Copper Gluconate Choline Bitartrate Dicalcium Phosphate 120 MG L-Potassium Aspartate 30 MG Propionyl-L-Carnitine 1000 MG L-Asparagine 650 MG Acetyl-L-Carnitine 500 MG L-Potassium Aspartate 150 MG Caffeine (USP) 125 MG L-Tyrosine: 1800mg Acetyl L-Carnitine: 500mg Sulbutiamine: 300mg Rhodiola Rosea: 200mg -(standardized to 3%) Vinpocetine: 20mg Pyrodoxine HCL: 8mg

Camellia Sinensis 60% Polyphenols (green leaves), Yohimbine Alkaloids (pausinystalia yohimbe bark), 6’ 7’-Dihydroxybergamottin (fruit), Camellia Sinensis 60% Polyphenols (white leaves), Capsaicin (fruit)

Stimulant X www.stimulantx.com

Most frequently prescribed MAOIs include Nardil, Parnate, and Elderpril.

Nicotinic analogues

Gotu Kola - claim that oldest man who ever lived (chinese dude claimed to be over 200 years old) was taking tons of this stuff.

Take CEE and some adaptogens

AMP or Focus XT for a neural boost

Panax ginseng

Palatinose + extra citrulline malate + extra beta alanine + ALCAR + Tyrosine synergy

Maca - traded as currency amongst spanish colonials once

Ergopharm's amp...stimx, pumpjuice2.0 (not just a stim).

Glucuronolactone

XCeed is a CEE

Yerba mate

PW could definitely help out. Cordygen5 and Citruvo: Improves endurance, strength, oxygen efficiency, ATP production

Thermolife Stizm. WOW excellent reviews

Metformin
The mechanisms for lifespan extension by metformin are not completely understood yet but probably involve AMPK and its downstream target mTOR (fig. 1) (4). mTOR is also the target of the famous life extension drug rapamycin that increases lifespan in mice both when administered early and during middle life (15,16). mTOR inhibits autophagy thus metformin activates autophagy by inhibiting mTOR. Autophagy clears cells from dysfunctional organelles – such as mitochondria – and other junk that can impair normal cellular functions and thereby extends lifespan. mTOR stimulates protein synthesis and for still very incomplete understood reasons protein synthesis reduces lifespan. Therefore again metformin is expected to retard aging. If the cell cycle is arrested – that is the cell temporally stops dividing – and the cell continues to receive growth signals (mTOR stays active), it can lead to cell senescence – a state of permanent cell cycle arrest (4). Senescent cells secrete proinflammatory molecules, this has been termed the senescence-associated secretory phenotype, and can locally stimulate tumor growth (17). Metformin is expected to prevent cell senescence by removing the growth signal pressure. AMPK inhibits NAD(P)H oxidase, an enzyme whose action produces superoxide – a free radical. Metformin thus decreases free radical production (4). Free radicals are molecules that have an unpaired electron, they desperately try to find an extra electron to stabilize their configuration and in the process destroy other molecules by stealing their electrons. The free radical theory of aging is without doubt the most well known mechanistic aging theory. It was first proposed by Denham Harman in 1956 (18). Since then the failure of antioxidants to extend the lifespan has cast doubt on the validity of the free radical theory but still most biogerontologists think that free radicals do play a certain role. In fact some even suggest that the failure of antioxidants is expected because they undermine the bodies stress response (19). AMPK can be activated by: (i) binding of AMP, and (ii) phosphorylation by other enzymes. Metformin has clearly been shown to increase the phosphorylation of AMPK but the effects on AMP are disputed. Phenformin and buformin inhibits complex I of the respiratory chain, so maybe metformin does so too. Such an inhibition would decrease ATP – the universal energy currency for life – production and thereby increase AMP levels.

Phenylpiracetam, Phenotropil, Fenotropil, Carphedon

Fenotropil has a positive effect on metabolism and blood circulation within the brain. It stimulates the Redox processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in Ischemic areas of the brain. Moreover, it increases noradrenaline, dopamine, and serotonin brain levels. It does not affect GABA levels and is not associated with GABA A- and -B receptors. It produces no significant effect on spontaneous brain activity.

Fenotropil has no effect on the respiratory and cardiovascular systems. However, it produces a mild diuretic effect and anorexic activity in the exchange application.

Fenotropil provides a moderately stimulating effect on motor responses and improves physical performance. The moderate awareness-inducing effect of the drug is combined with anxiolytic activity. Fenotropil improves mood and has analgesic effects, increasing the pain threshold. Additionally, it has an adaptogenic effect, increasing the organism's resistance to stress in conditions of increased mental and physical stress and fatigue. Furthermore, it increases resistance to freezing hypokinesia.

With the advent of Phenotropil, marked improvements were noted in vision (an increase in sharpness, brightness, and field of view). Fenotropil improves blood flow to the lower extremities. Fenotropil stimulates the production of antibodies in response to the antigen, indicating that it has immunostimulator properties but at the same time does not cause the development of immediate hypersensitivity reactions and does not alter the allergic inflammatory reaction of the skin caused by the introduction of foreign proteins. In the exchange application, Phenotropil does not develop drug dependence and tolerance. The drug is not marked in the development of withdrawal syndrome.

Actions of Fenotropil are seen after a single application, which is important when the drug is used in extreme conditions. Phenotropil significantly enhances the action of other Nootropic drugs.

Fenotropil is not metabolized in the body and excreted, unchanged in form. About 40% is excreted in the urine and 60% in bile and sweat. The half-life is 3-5 hours. The average single dose is 150 mg (100-250 mg); the average daily dose is 250 mg (200-300 mg). The maximum daily dose is 750 mg. The multiplicity of reception is 1-2 times a day. A daily dose of 100 mg can be taken one time a day (morning), while doses exceeding 100 mg should be taken in two doses. The duration of treatment ranges from two weeks to three months. The average course of treatment is 30 days.



RECREATIONAL SUBSTANCES WORTH RESEARCHING:

Dimoxamine

DOM

2C-I

2C-I and 2-CT-2

2C-I (2,5-dimethoxy-4-iodophenethylamine) Most likely candidate for the coveted title "the next ecstasy".

http://medi.ru/doc/3101.htm http://www.phenotropil.ru/pub/ kunwha.com


Cerebrolysin has to be injected intravenously or intramuscularly. It cannot be injected into the fatty tissue. An intramuscular (IM) injection is a shot where the needle goes into the muscle layer under the skin to deliver medicine. IM injections are deeper than subcutaneous injections (given under the skin). Parts of the Body Involved - Upper arm, Top of the thigh, Buttocks (most common and recommended for 5 ml cerebrolysin injections).

A needle passes through skin and fat layers into the muscle fibers to deliver medicine.

http://www.longecity.org/forum/topic/28171-cerebrolysin/


NOTES:

I have a few questions if you wouldn't mind answering them?

1) How long did you use it for? I beleive there's five 5 ml ampoules in each packet. It sounds like you took 5 ml (first day), 5 ml (2nd day), 10 ml (3rd day), then possibly 5 ml the 5th day if you used all the ampoules up?

2) Dosaging Instructions According to Antiaging-Systems: The normal dosage pattern seems to be to do an injection 5 days out of a 7 day week for 4 weeks. Alzheimers patients (or possibly certain people suffering a delay of some sort to a lesser severity) would take 1 ml, 5 ml, or 10 ml ampoules once a day Mon.-Fri. (or whatever's 5 days; skipping 2 days each week) for 4 weeks (before waiting 3 months to begin again). The benefits are supposed to last possibly up to 3-6 months.

With that being said, 10 ml seems like it could potentially be a bit much for a healthy person to take. Did you notice a direct difference between the 5 ml on the 1st day vs. the last day? Or the 5 ml (from the 1st and last day) vs. the 10 ml?

3) Any dizziness, headache, or heat sensations? According to http://www.antiaging...erebrolysin.htm these are some rarer side-effects that may occur if administered too quickly? (meaning possibly jumping right up to 10 ml could of been done too quickly?)

4) It doesn't appear side-effects are common. Perhaps a healthy person could order 10 1 ml ampoules (this is much cheaper for around $50) instead of the 5 5ml (around $70) or 5 10ml (around $90). This would mean for $100 someone could do the 4 week program using only 1 ml ampoules instead of paying around $280 for a 4 week program using 5 ml ampoules.

5) I don't want to throw this thread off track here but have you heard of "Cortexinum"?http://www.pharmacy1...age.asp?id=1375 It seems surprisingly similar to Cerebrolysin. I'm wondering if this is some sort of Russian variant brand of Cerebrolysin?


I will post this again:

There are no Cerebrolysin alternatives which can be taken orally except N-PEP-12(MemoProve) which is a derivative of Cerebrolysin and it is much less potent.

Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com


1) I had 2 packs of cerebrolysin. I used 5 ml for the first 3 days and 10 for ml for 2 days.

2) I did not notice anything for the first 2 days. The effect became really noticeable on the 3rd day, even more noticeable on 4th and 5th. Btw, 1 ml ampules are usually given to kids.

3) I did not feel any dizziness, headache, or heat sensations. Those side effects usually occur when you inject a cold liquid intravenously. To avoid this it has to be warm enough (room temperature) and you have to inject it slowly.

4) 1 ml is a very small dose, it is not enough even for a healthy adult. I have read the instructions and it says that doses of 1-2 ml are given to kids. Doses up to 50 ml (IV) can be given in severe cases. Cerebrolysin is overpriced if you buy it online. I bought another pack of cerebrolysin while traveling in one of the EU countries, the price at the pharmacy was 34 USD (5 x 5ml amp)

5) If I remember correctly cortexin is made from cattle brain. I will try to get some more info about it. Edited by anony4mous, 22 April 2009 - 01:32 AM.



Cortexin peptide drug is largely similar to the cerebrolysin, used also by intramuscular injection./Pharmacological Effects: The drug improves cerebral metabolism. Cortexin represents liofilizat obtained by acetate extract from the bark of the brain of cattle or pigs, which contains low-molecular active neuropeptides, the molecular weight of not more than 10 000 dalton, sufficient to penetrate through hematoencephalic barrier./Cortexin has a unique multi-effects on the brain, as demonstrated in metabolic regulation, neuropatronage, functional neuromodulation, neurotrophic activity. Cortexin improves the efficiency of energy metabolism of brain cells, improves the intracellular synthesis of protein, regulates the processes of oxidation of lipids in cells of the brain reduces the formation of free radicals, blocking the processes of free-radical oxidation. The product eliminates the imbalance of braking and excitatory amino acids, has a moderate GABA-ergic action./The drug has a positive effect in violation of cognitive function, improves concentration, short-term memory, learning ability, accelerates the recovery of the functions of the brain after stress effects, regulates the levels of serotonin and dopamine. It stimulates the process of mental activity, not providing excessive activation of influence, restores bioelectric activity of the brain, stimulates the reparative processes in the brain./Indications for use: Violations of the cerebral circulation; encephalopathy of different genesis, acute and chronic encephalitis and encephalomyelitis, epilepsy, brain trauma, viral and bacterial neuroinfection; infantile cerebral palsy, delayed psychomotor and speech development in children; asthenia, memory, thinking, reducing the ability to learn.


Concentrate always means - impure. Hydrolyate means a more exact synthesis of adding hydrogen to the the purified mix. Both kinda suck, because all you want is the chemical, but what the process gives you, is impurities. The more you get rid of that - the higher the costs get.

I was taking up to 10 ml of cerebrolysine daily at work though I/M injections, easily for a good 6 months if not more. (Usually in 2 injections, although I've shot 10ml straight up before in one large syringe) Since I worked in 4-day shifts, I'd usually go 4 days on and then 4 days off to cool off my neurons  That easily allowed me to handle all the stresses, and I was one of the best at that particular job. Despite having abused illegal drugs in the past and being a frequent cannabis smoker, I experienced little to no "stoner burnout" and was able to concentrate and perform tasks faster than most of my colleagues at the same experience level. After a long 12-hour work day, after which a normal brain turns to mush, I was still fresh and eager to go out with friends/ see girls etc, while otherwise I'd be drained and only wanting to sleep.


So instead of rambling on further, let me just break down some effects and side-effects, short and long term:

-This stuff has a MARKED anti-depressant effect. You basically feel like back in the happiest moments of your childhood. Everyone has had one of those days when they're just "on fire" and "on top of the game". With Cerebrolysine, pretty much every day is like that - you're not overly happy or vegetated like off standard anti-depressants, but you're "on point" at whatever you do. Stuff like your subconscious and conscious fears all go right out of the window, and it has a bit of a socially-inhibiting effect too.

-If you thought weed gets you the munchies, wait till you try this stuff. When you first start on this cycle, you get hungry as a SAVAGE. I usually eat just enough to be full, not overly gorged, but this stuff had me tearing up huge meals and not even feeling incapacitated by everything I just ate. I'd attribute this to the fact that with all the additional peptides and stuff, your body needs more nutrition. Sort of like adding B-vitamins to stuff like Pyritinol or even good old 5-HTP.

-Cerebrolysine helps alleviate most, if not all symptoms of post-intoxication syndrome for illicit drugs. I once gave my friend a shot after his most recent cocaine binge and he turned from a pale shadow who was about to pass out back to his normal self - energetic, enthusiastic, and motivated. Plus his foul mood and edginess were completely gone. It also seems to ease the alcohol-related hangover better than some other substances (although many nootropics are much better for that IMO since they're GABA-active). My other friend also liked taking it as a "corrector agent" for other nootropics/supplements, claiming it helped alleviate certain unwanted effects of piracetam, while preventing one from overloading on one particular amino acid too much. I personally avoid ALL other substances when doing cerebrolysine. It simply overshadows them all for me.

-They definitely put some kind of a painkiller in there. Shooting cortexin (which is similar, but I like it alot less, as it "vegetates" and sedates me too much to where I'm more mentally capable, but simply don't care) without a novacaine solution is literally a huge pain in the rear, while shooting straight cerebrolysine into my tiny tricep with a huge needle made my whole arm go numb for a short time, like an anastetic would.

-I've measured my blood pressure several times before and after the injections, and there is a slight blood pressure elevation. If you inject too fast, the heart rate jumps and you may sweat profusely. However it gives you a nice sort of a "rush" to where you feel very relaxed, but not incapacitated or drugged by any stretch of imagination. The headaches are there, but are very slight, and usually start about 2-3 hours after the injection.

-The long-term effects aren't so pleasant. There is an increasing feeling of "mounting personal hell" as I like to call it. Basically, all the negative traits of one's character seem to be unnaturally emphasized and underlined in your mind, while the positives seem little and insignificant. It doesn't really manifest itself in a severe form to others, but you may feel "grumpy" and "dissatisfied" even when you seem to be razor-sharp mentally. A good comparision would be some rich spoiled kid who has everything throwing tantrums and breaking stuff, just because he is rich and spoiled. Several of my friends reported very similar mental side effects. This is what initially led me to stop taking it by "tapering down" (I don't think it's a good method by the way, but since I was doin it daily for a while I decided for a slower descent). A .5 ml less every day for several days, then a week at 1ml and then 0.5 and then you're shooting colored water for placebo effects

- Some people report a HUGE boost in their sexual activity. I noticed only a slight boost

- When you're off the cerebrolysine, you feel like it's a bad day for no reason (see above having a top of your game day for no reason lol). I didn't notice any significant negative long-term effects on my cognitive processes. On the contrary I seem to be able to concentrate better at any time, without taking any substances, or even after smoking a lot of weed. I'm now able to "zone in" on something more completely and do better at focusing.

-This stuff has very strong and powerful overall effects, it is the most effective out of injectable nootropics/smart drugs that I've tried. Cortexin doesn't even come close, and various Cerebrolysine derivatives (we ahve a Cerebrolysate here) are nothin more than cheap imitations.

I've decided for another mini-cycle just now, about 3 years after that last lengthy episode. I'm sticking to what the doctors here recommend: 5ml every OTHER day. Seems to be the correct dosage and schedule.

I hope it doesn't sound too much like promo for the Austrian pharmaceuticals company which makes this stuff. It's really not somethin you want to mess around with if you don't know what you're doing.

http://www.longecity.org/forum/topic/28171-cerebrolysin/page__st__30



FASCINATING INFO ON AGING:

THE FOUR CRIMINALS BEHIND AGING: 1. Methylation 2. Oxidation 3. Glycation 4. Inflammation


Glycation, Methylation, Inflammation, Oxidation


Glycation is a chemical process that takes places in the body, which binds sugar and proteins. This binding with sugar makes the structural proteins in your body stiffer and contributes to accelerated aging by reducing flexibility of tissues and organs.

The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases.[8] AGEs have been implicated in Alzheimer's Disease,[9] cardiovascular disease,[10] and stroke.[11] The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis. They form photosensitizers in the crystalline lens, which has implications for cataract development.  Reduced muscle function is also associated with AGEs.

It is not yet clear whether glycation can actually be reversed, however research is currently being conducted on a class of chemicals called AGE breakers. These drugs would theoretically “undo” the damage in glycated tissues, returning them to their normal state.

For all the promise of youth-restoring remedies none has ever reversed the process of aging. Now, for the first time, researchers at Alteon Inc. (alteonpharma.com) have developed a drug that rejuvenates hearts and blood vessels, stiffened with age, by breaking up molecules that cause the trouble.

Anti AGEs

Elusive alt-711 (alagebrium)

Aminoguanidine

NtBHA (Geronova)

N-acetyl-L-carnosine (NALC) (Superior Nutraceuticals)



OTHER NOTES: MDD

Quercetin

Fisetin

Similar to many other flavonoids such as the structurally related flavonol quercetin, fisetin is a potent antioxidant. Its antioxidative activity may be due to its structural properties as well as to its ability to modulate certain cellular signaling pathways, especially protein kinase and lipid kinase pathways. For example, fisetin has been shown to induce the transcription factor Nrf2, leading to increased expression of several protective and antioxidative genes. One study at the Salk Institute found that fisetin may help improve memory and protect the brain from the onset of Alzheimer's disease and also that it may be useful for reducing kidney failure in diabetics.

Side effects Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor. This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.  Fisetin among other flavonoids is suspected to increase risk of infant leukemia (which is rare disease).


Rapamycin
Rapamycin was first shown to extend lifespan in eukaryotes in 2006. Powers et al. showed a dose-responsive effect of rapamycin on lifespan extension in yeast cells. Building on this and other work, in a 2009 study, the lifespans of mice fed rapamycin were increased between 28% and 38% from the beginning of treatment, or 9% to 14% in total increased maximum lifespan. Of particular note, the treatment began in mice aged 20 months, the equivalent of 60 human years. This suggests the possibility of an effective antiaging treatment for humans at an already-advanced age, as opposed to requiring a lifelong regimen beginning in youth. Because it strongly suppresses the immune system, though, people taking rapamycin are more susceptible to dangerous infections. It is not known whether rapamycin will have similar lifespan-lengthening effects in humans, and study authors caution the drug should not be used by the general population for this use until more is known about the substance.

Omega-3 EPA/DHA  http://j.mp/yoYGvO

Furazabol
Furazabol is for cutting, vascularity, weight, cholesterol improvement:  However, recently 100 mg/mL versions have become available. A common dosage can be 10–25 mg/day orally and 25–50 mg daily injected, with optimal results usually seen at 50 mg/day.

Cimaterol
The best choice for weight control and even fat-burning appears to be Cimaterol.  Investigate further.

L-tartrate

Cytomel
There are many advantages to using Cytomel to optimize our metabolic rate. It will also increase your bodys ability to synthesize protein, but from what Ive seen personally, it acts as a catabolic when it isn't administered with anabolic steroids. It is often the last thing added into a pre bodybuilding contest diet as it has a reputation for getting rid of the last few percentages of bodyfat& the "sticky fat" as its called in bodybuilding, the fat that just doesnt want to leave you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a diet to lose fat, as it will optimize your metabolic rate, which should be done at the outset of a diet, not after the calorie restriction has diminished your thyroid output and you are adding it in simply to replace what was lost. Read more: http://www.steroid.com/Cytomel.php#ixzz1iwD2YLl4

Clenbuterol Most users experience a very strong energy rush within 15 minutes of each dose. This characteristic makes it a popular pre-workout intensity pill and thermogenic.  Approximately 8% of users experience a paradoxical effect and become a bit lethargic.

Galantamine used with choline bitartrate or Alpha-GPC Galantamine has been used as a neuroprotectant and sleep aid, Galantamine can help people fall asleep and also increase sleep-stage quality.

7-amino-8-hydroxbutyric acid (GABOB) worth researching for sleep and anxiolytic.

chocamine+deprenyl+inositol+bacopa+sam-E interesting combination for cognitive enhancement.  Another would be 1 gram of L-theanine, 1 gram of Green Tea, Fish Oil, and two amp.

Ma-huang (oral) and or Sida cordifolia (oral) / Or ephedrine HCL

(K)-R-ALA (oral)

XCeed is a CEE with some other boosters

Try Yerba Mate wisdom of the ancients vanilla / and guayaki's

Cordygen5 and Citruvol may be a great combination


Interesting understanding:

Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

"Antidepressant" and "euphoriant" are distinct, and we have various classes of drugs that can select pretty effectively either one or the other effect.  There are also certain classes of drugs which may produce both a euphoric and an antidepressant effect, for example: Nardil, Parnate, Amineptine, Ketamine, Cannabinoids, and the endorphin release triggered by opiates etc.

Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats. http://www.ncbi.nlm.nih.gov/pubmed/22135908

Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Finally, increasing CREB expression after withdrawal from self-administration enhanced cocaine-primed relapse, while reducing CREB levels facilitated extinction of cocaine seeking, but neither altered relapse induced by cocaine cues or footshock stress.

Dopamine types: D1 dysphoric D2 euphoric

What I've read about Memantine on a large number of internet sites tells me it is believed to work by protecting nerve cells from being killed off by glutamate toxicity. This happens in Alzheimer's when a certain type of receptor on the cells, the NMDA receptor, is over-stimulated by glutamate and releases an overload of calcium into the cell, causing aptosis / excitotoxicity. Memantine regulates the calcium ion inflow by partially blocking the NMDA receptor. Although memantine is a patented prescription NMDA blocker, so too are a number of non-prescription nutriceuticals.  Among them are: Huperzine-A, which aside from its primary action as a a cholinesterase inhibitor will also protect the brain from glutamate excitotoxicity.  Theanine, is a derivative of green tea, and a potent DA producer (I do not believe this is via a conversion into L-Dopa, then Dopamine, much the way many Alzheimers drugs work, rather I think it sponsors a spike in endogenous production of the DA neurotransmitter) also.  L-theanine has a paradoxical relaxing effect and is believed to be the agent that counters the stimulating and sometimes anxiety producing effects of caffeine contained in most green teas.  L-theanine typically has anxiolytic and mood-elevating effects without drowsiness.

Vitamin E and the methylcobalamin form of B12 are effective neuroprotectants.  The Lithium info I found recently, and it is being considered for Alzheimer's trials. As it's available in safe supplement form as lithium orotate, I give her that also, (one capsule daily) and it does seem to be giving her an extra improvement in mood, and she has a good sense of humour, often with fits of giggles! I read about the effects of Lithium orotate at a number of sites. It should be stressed that this only applies to the orotate form of lithium, which is non-prescription yet still effective at stabillizing mood.

Should investigate OPCs.  Basically they're polyphenols, principally Proanthocyanidin.  The group are powerful antioxidants that have recently been stabilized and made bioavailable.

Enhancing BDNF in the NAA produces a behavioral depressant effect whereas the opposite is true to increasing BDNF in the hippocampus.

Endomorphin-1 (Tyr-Pro-Trp-Phe-NH(2)) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)) are two recently isolated mu-opioid selective peptides with a potent antinociceptive activity, involved in a number of physiological processes, including food intake, vasomotricity, sexual behavior, as well as neuroendocrine and cardiorespiratory functions. The neuroanatomical distribution of endomorphins prompted us to study their antidepressant activity in two animal behavioral models of depression: forced-swimming and tail-suspension tests. In both tests, the intracerebroventricular (i.c.v.) injection of either endomorphin-1 or endomorphin-2 significantly decreased the duration of immobility, interpreted as an expression of 'behavioral despair', which could be related to the depression syndrome. These effects of endomorphins did not result from the stimulation of the animal motor activity. We have also demonstrated that the antidepressant-like effect of endomorphins was antagonized by the universal opioid antagonist, naloxone and the mu-opioid receptor selective antagonist, beta-funaltrexamine. In contrast, this effect was not antagonized by delta- and kappa-opioid receptor selective antagonists, naltrindole and nor-binaltorphimine, respectively. The results of the present study demonstrate that endomorphin-1 and endomorphin-2 produce potent antidepressant-like effects after i.c.v. injection in mice. We may suggest that endomorphins and the mu-opioid receptors might be involved in the physiopathology of depressive disorders, and that the endomorphinergic system could serve as a novel target for the development of antidepressant drugs.







My Current Supplement Regimen:

Pramiracetam

Hydergine

Idebenone



Considering taking:

Roxindole

Phenylpiracetam

Carphedon or Phenotropil

Adapton Iherb.com - TERRIBLE fish smell, no noticable effects after a couple of months taking it


Interesting posts:

Morphine, a mood brightening smart drug http://opioids.com/cogmood/morphine.html

Case studies, long term relief of depression in highly refractory cases with fixed doses of oxycodone. http://opioids.com/antidepressant/opiate.html

Use of opiates in highly refractory AD and ECT nonresponse. http://opioids.com/antidepressant/opiates.html

The DST and as predictor of response to opiates. http://opioids.com/antidepressant/depression-subtypes.html

Methadone and morphine in depression http://opioids.com/antidepressant/index.html

The antdepressant effect of endomorphins. http://opioids.com/endomorphins/antidepressant.html

http://www.druglibrary.org/Schaffer/heroin/methadone/toxicity.htm

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=substance+P+inhibitors#hl=en&expIds=17259,17315,18167,20782,23628,23670,23945,25646,25834,25907,26328,26637,26746,26761,26849,27000&sugexp=ldymls&xhr=t&q=substance+P+produce+euphoria&cp=28&pf=p&sclient=psy&safe=off&aq=f&aqi=&aql=&oq=substance+P+produce+euphoria&gs_rfai=&pbx=1&fp=8d771dec467097a5

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=PEPTIDE+TRANSMITTERS:+A+UNIFYING+HYPOTHESIS+FOR+EUPHORIA,+RESPIRATION,+SLEEP,+AND+THE+ACTION+OF+LITHIUM

http://www.dr-bob.org/babble/alter/



Possible new stimulants / euphoriants / and pro-social substances and compounds:

"Substance P"

NK1 receptor antagonist or inhibitor significant increase in dopamine secretion into the nucleus accumbens

These data attest to the reinforcing characteristics of an enkephalin analog

Natural polypeptides may contribute to the reinforcing properties of opiate drugs.

Acute administration of short-acting opiates in animal models causes a reduction in FSH and LH levels, a reduction in glucocorticoid levels, and an increase in prolactin levels. In studies of methadone-maintained patients, several workers have found that plasma levels of FSH and LH may be significantly reduced in some patients during the first year of chronic treatment (Table 7). In both prospective and special studies, it has been shown that levels of these hormones returned to normal after two or more years of chronic methadone treatment. However, we have found that testosterone may remain decreased in around 20-30% of patients after one year of chronic treatment.

It has been well-documented that the acute or subacute administration of narcotics to humans results in a predictable significant reduction in plasma cortisol levels, presumably reflecting a reduction in ACTH levels. It has also been shown that during cycles of subacute or chronic morphine administration in former heroin addicts, both cortisol levels and total urinary excretion of glucocorticoids are reduced. However, our group and others have shown that during chronic long-term methadone administration, plasma cortisol levels are within normal range with a brisk but normal circadian variation.7, 88, 25, 37 In recent studies to be discussed in more detail, we have also shown that plasma levels of ACTH are normal in patients during chronic long-term methadone maintenance treatment.37 In early studies reported in 1972 and 1974, we have found that during the first 2 months of chronic methadone treatment, significant alterations of function of the hypothalamic-pituitary adrenal axis do exist, as evidenced by abnormal metyrapone test results, indicating reduced hypothalamic-pituitary reserve for release of tropic hormones.8, 25 We showed that tolerance develops to this effect after three or more months of stabilized methadone treatment.











































































ANTI AGING DOCTOR LIST BELOW:

REGIMEN:
PQQ (pyrroloquinoline quinone) 50mg's/day Aniracetam 750 mg each /4X/day Centrophenoxine 500 mg 4/day x 4 days on, 4 days off Acetyl-L-Carnitine 500 mg / 3 - 4 per day (high dose) DMAE Bitartrate 150 mg / 3 per day Alpha GPC 300 mg each / 2 per day Omega-3 EPA/DHA  2x day http://j.mp/yoYGvO http://j.mp/slash-risk-of-premature-death-85-percent 5-MTHF 50mg / 1X day Pyritinol 400 mg each / 1 per day CDP Choline 250 mg / 2 per day Idebenone 180mg  / 1 - 2 per day Life Extension Super Ginkgo 120mg / 2 day Ubiquinol Benfotiamine Rhodiola
Phosphatidylserine  http://j.mp/zGl4hK S-adenosylmethionine http://j.mp/Aisb71


Interesting pharma or RC ("research chemical"):

Prolintane aka Catovit

1-(thien-2-yl)isopropylamine

Butylone


Interesting Nootropic: Rolipram (http://j.mp/rolipram)

CX717
“It generates a state of cortical wakefulness without stimulation,” says Gary Lynch at the University of California at Irvine, who invented ampakines. Cortex Pharmaceuticals Inc., based in Irvine, California

Ampakines work by binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. And because of their short half-life - hours in this case - ampakines have few side effects.

Rasagiline & Selegiline By inhibiting MAO-B, rasagiline prevents the deamination of the monoamines dopamine and phenethylamine (PEA), thereby increasing their concentration in the synapse and curbing production of the reactive oxygen species, hydrogen peroxide. High concentrations of hydrogen peroxide are associated with increased oxidative stress. Rasagiline both raises levels of striatal dopamine produced from levodopa and improves the survival prospects of ailing dopaminergic neurons themselves. This salvage job helps restore a measure of normal locomotion, gait and coordination in Parkinsonian patients while delaying their physical decline.

Both selegiline and rasagiline are neuroprotective via multiple mechanisms that are poorly understood. However, their role in stabilising mitochondrial membrane potential is critical. The propargylamine moiety rather than MAO inhibition per se apparently holds the key to their neuroprotective action: the S isomer of rasagiline is some 1000 times less potent as an MAO inhibitor, but it's still protective against neurotoxic insults. Rasagiline inhibits activation of the apoptotic cascade triggered by dopamine neurotoxins and oxidative stress. Apoptosis is an active process of programmed cell-death induced by exposure to neurotoxins. Rasagiline and other propargylamines can rescue deteriorating dopaminergic neurons by inhibiting the "death signal" transduction-mechanism of mitochondrial permeability transition. Current evidence suggests that rasagiline may be more effective than selegiline in salvaging dopamine nerve cells from the usual neurological carnage of later life.


Two fascinating Russian chems and experience reports:

Cerebrolysin It's the second day I take cerebrolysin only. The effect is very interesting, I wake up very energetic, my sensitivity to caffeine has increased a lot. A cup of espresso is too much for me.

Cerebrolysin appears to have some kind of antidepressant / anti-anxiety effect. I have never used anxiolytics or antidepressants before but I noticed that I don't feel depressed or anxious under extremely stressful situations. I had trouble getting asleep as well, but now I just go to my bed and I get asleep in 10-15 mins.

Cerebrolysin probably does not have a typical antidepressant / anxiolytic affect. I guess that you can only notice the effect of cerebrolysin if you have to undergo extremely high workload, stressful situations... I simply don't get tired and I can relax much easier after any stressful event

This nootropic is one of those which have a very pronounced effect and it scares me  To be honest, it is one of the reasons I will not continue taking cerebrolysin. Nobody knows what are the long term effects of this drug. I am a healthy individual, so I don't see any need to take a risk and use it any longer. However it was a positive experience


Phenotropil works wonders when I take it with Semax.

The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"

It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.

Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.

As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.

I hope this is useful to everyone interested in this peptide.


Fascinating Nootropic and notes + list:

Noopept.

1010pharma.com is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax right now, anti-aging.com may carry...

One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

http://www.apteka-dr...erc-3ml-n1.aspx

phenylpiracetam

http://www.backtone.com/

N-PEP-12(MemoProve) which is a derivative of Cerebrolysin

Memantine - Namenda

Alpha GPC

Selegiline - Deprenyl

Horny goat weed - Same as above. PDE5 inhibition could be helpful as well on occasion (those first couple hours of amphetamine are brutal).

Agmatine - It's an obscure possible neurotransmitter produced from arginine that among many possible benefits blocks NMDA receptors and thus hopefully helps mitigate amphetamine tolerance. It may improve mood, memory, and sleep as well.

Phenibut, while I loved the initial effects, became detrimental VERY FAST (depressant action). So 2-3 times a week seems too much to me. Just be aware of this.

Huperzine A - NMDA. Hopefully some memory improvement. I've read that this may be dangerous to take regularly so I will probably go with 200mcg every other day. If taking any of these drugs for depression, be very careful with Huperzine A.

Green tea extract - It's high in ECGC. Good anti-oxidant. I will likely take this daily.

Bacopa - I took it regularly for about three weeks, one dose in the evening. It can make you a bit drowsy.

Magnesium Glycinate - best form of magnesium to take.

L-Theanine - Fantastic DA augmentor.

Sulbutiamine 300mg -Sulbutiamine is a funny substance. It's amazing at first. Many have noticed it decreases creativity to an extent, which I would tend to agree with. But it should also be used very sparingly-- tolerance will develop. Because of the receptors it antagonizes/agonizes, its effects are much more pronounced with caffeine. I.e., it is synergistic.

Interesting nutra to consider taking or taking more regularly: DL-Phenylalanine Yohimbe
L-Tyrosine Copper Gluconate Choline Bitartrate Dicalcium Phosphate 120 MG L-Potassium Aspartate 30 MG Propionyl-L-Carnitine 1000 MG L-Asparagine 650 MG Acetyl-L-Carnitine 500 MG L-Potassium Aspartate 150 MG Caffeine (USP) 125 MG L-Tyrosine: 1800mg Acetyl L-Carnitine: 500mg Sulbutiamine: 300mg Rhodiola Rosea: 200mg -(standardized to 3%) Vinpocetine: 20mg Pyrodoxine HCL: 8mg

Camellia Sinensis 60% Polyphenols (green leaves), Yohimbine Alkaloids (pausinystalia yohimbe bark), 6’ 7’-Dihydroxybergamottin (fruit), Camellia Sinensis 60% Polyphenols (white leaves), Capsaicin (fruit)

Stimulant X www.stimulantx.com

Most frequently prescribed MAOIs include Nardil, Parnate, and Elderpril.

Nicotinic analogues

Gotu Kola - claim that oldest man who ever lived (chinese dude claimed to be over 200 years old) was taking tons of this stuff.

Take CEE and some adaptogens

AMP or Focus XT for a neural boost

Panax ginseng

Palatinose + extra citrulline malate + extra beta alanine + ALCAR + Tyrosine synergy

Maca - traded as currency amongst spanish colonials once

Ergopharm's amp...stimx, pumpjuice2.0 (not just a stim).

Glucuronolactone

XCeed is a CEE

Yerba mate

PW could definitely help out. Cordygen5 and Citruvo: Improves endurance, strength, oxygen efficiency, ATP production

Thermolife Stizm. WOW excellent reviews

Metformin
The mechanisms for lifespan extension by metformin are not completely understood yet but probably involve AMPK and its downstream target mTOR (fig. 1) (4). mTOR is also the target of the famous life extension drug rapamycin that increases lifespan in mice both when administered early and during middle life (15,16). mTOR inhibits autophagy thus metformin activates autophagy by inhibiting mTOR. Autophagy clears cells from dysfunctional organelles – such as mitochondria – and other junk that can impair normal cellular functions and thereby extends lifespan. mTOR stimulates protein synthesis and for still very incomplete understood reasons protein synthesis reduces lifespan. Therefore again metformin is expected to retard aging. If the cell cycle is arrested – that is the cell temporally stops dividing – and the cell continues to receive growth signals (mTOR stays active), it can lead to cell senescence – a state of permanent cell cycle arrest (4). Senescent cells secrete proinflammatory molecules, this has been termed the senescence-associated secretory phenotype, and can locally stimulate tumor growth (17). Metformin is expected to prevent cell senescence by removing the growth signal pressure. AMPK inhibits NAD(P)H oxidase, an enzyme whose action produces superoxide – a free radical. Metformin thus decreases free radical production (4). Free radicals are molecules that have an unpaired electron, they desperately try to find an extra electron to stabilize their configuration and in the process destroy other molecules by stealing their electrons. The free radical theory of aging is without doubt the most well known mechanistic aging theory. It was first proposed by Denham Harman in 1956 (18). Since then the failure of antioxidants to extend the lifespan has cast doubt on the validity of the free radical theory but still most biogerontologists think that free radicals do play a certain role. In fact some even suggest that the failure of antioxidants is expected because they undermine the bodies stress response (19). AMPK can be activated by: (i) binding of AMP, and (ii) phosphorylation by other enzymes. Metformin has clearly been shown to increase the phosphorylation of AMPK but the effects on AMP are disputed. Phenformin and buformin inhibits complex I of the respiratory chain, so maybe metformin does so too. Such an inhibition would decrease ATP – the universal energy currency for life – production and thereby increase AMP levels.

Phenylpiracetam, Phenotropil, Fenotropil, Carphedon

Fenotropil has a positive effect on metabolism and blood circulation within the brain. It stimulates the Redox processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in Ischemic areas of the brain. Moreover, it increases noradrenaline, dopamine, and serotonin brain levels. It does not affect GABA levels and is not associated with GABA A- and -B receptors. It produces no significant effect on spontaneous brain activity.

Fenotropil has no effect on the respiratory and cardiovascular systems. However, it produces a mild diuretic effect and anorexic activity in the exchange application.

Fenotropil provides a moderately stimulating effect on motor responses and improves physical performance. The moderate awareness-inducing effect of the drug is combined with anxiolytic activity. Fenotropil improves mood and has analgesic effects, increasing the pain threshold. Additionally, it has an adaptogenic effect, increasing the organism's resistance to stress in conditions of increased mental and physical stress and fatigue. Furthermore, it increases resistance to freezing hypokinesia.

With the advent of Phenotropil, marked improvements were noted in vision (an increase in sharpness, brightness, and field of view). Fenotropil improves blood flow to the lower extremities. Fenotropil stimulates the production of antibodies in response to the antigen, indicating that it has immunostimulator properties but at the same time does not cause the development of immediate hypersensitivity reactions and does not alter the allergic inflammatory reaction of the skin caused by the introduction of foreign proteins. In the exchange application, Phenotropil does not develop drug dependence and tolerance. The drug is not marked in the development of withdrawal syndrome.

Actions of Fenotropil are seen after a single application, which is important when the drug is used in extreme conditions. Phenotropil significantly enhances the action of other Nootropic drugs.

Fenotropil is not metabolized in the body and excreted, unchanged in form. About 40% is excreted in the urine and 60% in bile and sweat. The half-life is 3-5 hours. The average single dose is 150 mg (100-250 mg); the average daily dose is 250 mg (200-300 mg). The maximum daily dose is 750 mg. The multiplicity of reception is 1-2 times a day. A daily dose of 100 mg can be taken one time a day (morning), while doses exceeding 100 mg should be taken in two doses. The duration of treatment ranges from two weeks to three months. The average course of treatment is 30 days.



RECREATIONAL SUBSTANCES WORTH RESEARCHING:

Dimoxamine

DOM

2C-I

2C-I and 2-CT-2

2C-I (2,5-dimethoxy-4-iodophenethylamine) Most likely candidate for the coveted title "the next ecstasy".

http://medi.ru/doc/3101.htm http://www.phenotropil.ru/pub/ kunwha.com


Cerebrolysin has to be injected intravenously or intramuscularly. It cannot be injected into the fatty tissue. An intramuscular (IM) injection is a shot where the needle goes into the muscle layer under the skin to deliver medicine. IM injections are deeper than subcutaneous injections (given under the skin). Parts of the Body Involved - Upper arm, Top of the thigh, Buttocks (most common and recommended for 5 ml cerebrolysin injections).

A needle passes through skin and fat layers into the muscle fibers to deliver medicine.

http://www.longecity.org/forum/topic/28171-cerebrolysin/


NOTES:

I have a few questions if you wouldn't mind answering them?

1) How long did you use it for? I beleive there's five 5 ml ampoules in each packet. It sounds like you took 5 ml (first day), 5 ml (2nd day), 10 ml (3rd day), then possibly 5 ml the 5th day if you used all the ampoules up?

2) Dosaging Instructions According to Antiaging-Systems: The normal dosage pattern seems to be to do an injection 5 days out of a 7 day week for 4 weeks. Alzheimers patients (or possibly certain people suffering a delay of some sort to a lesser severity) would take 1 ml, 5 ml, or 10 ml ampoules once a day Mon.-Fri. (or whatever's 5 days; skipping 2 days each week) for 4 weeks (before waiting 3 months to begin again). The benefits are supposed to last possibly up to 3-6 months.

With that being said, 10 ml seems like it could potentially be a bit much for a healthy person to take. Did you notice a direct difference between the 5 ml on the 1st day vs. the last day? Or the 5 ml (from the 1st and last day) vs. the 10 ml?

3) Any dizziness, headache, or heat sensations? According to http://www.antiaging...erebrolysin.htm these are some rarer side-effects that may occur if administered too quickly? (meaning possibly jumping right up to 10 ml could of been done too quickly?)

4) It doesn't appear side-effects are common. Perhaps a healthy person could order 10 1 ml ampoules (this is much cheaper for around $50) instead of the 5 5ml (around $70) or 5 10ml (around $90). This would mean for $100 someone could do the 4 week program using only 1 ml ampoules instead of paying around $280 for a 4 week program using 5 ml ampoules.

5) I don't want to throw this thread off track here but have you heard of "Cortexinum"?http://www.pharmacy1...age.asp?id=1375 It seems surprisingly similar to Cerebrolysin. I'm wondering if this is some sort of Russian variant brand of Cerebrolysin?


I will post this again:

There are no Cerebrolysin alternatives which can be taken orally except N-PEP-12(MemoProve) which is a derivative of Cerebrolysin and it is much less potent.

Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com


1) I had 2 packs of cerebrolysin. I used 5 ml for the first 3 days and 10 for ml for 2 days.

2) I did not notice anything for the first 2 days. The effect became really noticeable on the 3rd day, even more noticeable on 4th and 5th. Btw, 1 ml ampules are usually given to kids.

3) I did not feel any dizziness, headache, or heat sensations. Those side effects usually occur when you inject a cold liquid intravenously. To avoid this it has to be warm enough (room temperature) and you have to inject it slowly.

4) 1 ml is a very small dose, it is not enough even for a healthy adult. I have read the instructions and it says that doses of 1-2 ml are given to kids. Doses up to 50 ml (IV) can be given in severe cases. Cerebrolysin is overpriced if you buy it online. I bought another pack of cerebrolysin while traveling in one of the EU countries, the price at the pharmacy was 34 USD (5 x 5ml amp)

5) If I remember correctly cortexin is made from cattle brain. I will try to get some more info about it. Edited by anony4mous, 22 April 2009 - 01:32 AM.



Cortexin peptide drug is largely similar to the cerebrolysin, used also by intramuscular injection./Pharmacological Effects: The drug improves cerebral metabolism. Cortexin represents liofilizat obtained by acetate extract from the bark of the brain of cattle or pigs, which contains low-molecular active neuropeptides, the molecular weight of not more than 10 000 dalton, sufficient to penetrate through hematoencephalic barrier./Cortexin has a unique multi-effects on the brain, as demonstrated in metabolic regulation, neuropatronage, functional neuromodulation, neurotrophic activity. Cortexin improves the efficiency of energy metabolism of brain cells, improves the intracellular synthesis of protein, regulates the processes of oxidation of lipids in cells of the brain reduces the formation of free radicals, blocking the processes of free-radical oxidation. The product eliminates the imbalance of braking and excitatory amino acids, has a moderate GABA-ergic action./The drug has a positive effect in violation of cognitive function, improves concentration, short-term memory, learning ability, accelerates the recovery of the functions of the brain after stress effects, regulates the levels of serotonin and dopamine. It stimulates the process of mental activity, not providing excessive activation of influence, restores bioelectric activity of the brain, stimulates the reparative processes in the brain./Indications for use: Violations of the cerebral circulation; encephalopathy of different genesis, acute and chronic encephalitis and encephalomyelitis, epilepsy, brain trauma, viral and bacterial neuroinfection; infantile cerebral palsy, delayed psychomotor and speech development in children; asthenia, memory, thinking, reducing the ability to learn.


Concentrate always means - impure. Hydrolyate means a more exact synthesis of adding hydrogen to the the purified mix. Both kinda suck, because all you want is the chemical, but what the process gives you, is impurities. The more you get rid of that - the higher the costs get.

I was taking up to 10 ml of cerebrolysine daily at work though I/M injections, easily for a good 6 months if not more. (Usually in 2 injections, although I've shot 10ml straight up before in one large syringe) Since I worked in 4-day shifts, I'd usually go 4 days on and then 4 days off to cool off my neurons  That easily allowed me to handle all the stresses, and I was one of the best at that particular job. Despite having abused illegal drugs in the past and being a frequent cannabis smoker, I experienced little to no "stoner burnout" and was able to concentrate and perform tasks faster than most of my colleagues at the same experience level. After a long 12-hour work day, after which a normal brain turns to mush, I was still fresh and eager to go out with friends/ see girls etc, while otherwise I'd be drained and only wanting to sleep.


So instead of rambling on further, let me just break down some effects and side-effects, short and long term:

-This stuff has a MARKED anti-depressant effect. You basically feel like back in the happiest moments of your childhood. Everyone has had one of those days when they're just "on fire" and "on top of the game". With Cerebrolysine, pretty much every day is like that - you're not overly happy or vegetated like off standard anti-depressants, but you're "on point" at whatever you do. Stuff like your subconscious and conscious fears all go right out of the window, and it has a bit of a socially-inhibiting effect too.

-If you thought weed gets you the munchies, wait till you try this stuff. When you first start on this cycle, you get hungry as a SAVAGE. I usually eat just enough to be full, not overly gorged, but this stuff had me tearing up huge meals and not even feeling incapacitated by everything I just ate. I'd attribute this to the fact that with all the additional peptides and stuff, your body needs more nutrition. Sort of like adding B-vitamins to stuff like Pyritinol or even good old 5-HTP.

-Cerebrolysine helps alleviate most, if not all symptoms of post-intoxication syndrome for illicit drugs. I once gave my friend a shot after his most recent cocaine binge and he turned from a pale shadow who was about to pass out back to his normal self - energetic, enthusiastic, and motivated. Plus his foul mood and edginess were completely gone. It also seems to ease the alcohol-related hangover better than some other substances (although many nootropics are much better for that IMO since they're GABA-active). My other friend also liked taking it as a "corrector agent" for other nootropics/supplements, claiming it helped alleviate certain unwanted effects of piracetam, while preventing one from overloading on one particular amino acid too much. I personally avoid ALL other substances when doing cerebrolysine. It simply overshadows them all for me.

-They definitely put some kind of a painkiller in there. Shooting cortexin (which is similar, but I like it alot less, as it "vegetates" and sedates me too much to where I'm more mentally capable, but simply don't care) without a novacaine solution is literally a huge pain in the rear, while shooting straight cerebrolysine into my tiny tricep with a huge needle made my whole arm go numb for a short time, like an anastetic would.

-I've measured my blood pressure several times before and after the injections, and there is a slight blood pressure elevation. If you inject too fast, the heart rate jumps and you may sweat profusely. However it gives you a nice sort of a "rush" to where you feel very relaxed, but not incapacitated or drugged by any stretch of imagination. The headaches are there, but are very slight, and usually start about 2-3 hours after the injection.

-The long-term effects aren't so pleasant. There is an increasing feeling of "mounting personal hell" as I like to call it. Basically, all the negative traits of one's character seem to be unnaturally emphasized and underlined in your mind, while the positives seem little and insignificant. It doesn't really manifest itself in a severe form to others, but you may feel "grumpy" and "dissatisfied" even when you seem to be razor-sharp mentally. A good comparision would be some rich spoiled kid who has everything throwing tantrums and breaking stuff, just because he is rich and spoiled. Several of my friends reported very similar mental side effects. This is what initially led me to stop taking it by "tapering down" (I don't think it's a good method by the way, but since I was doin it daily for a while I decided for a slower descent). A .5 ml less every day for several days, then a week at 1ml and then 0.5 and then you're shooting colored water for placebo effects

- Some people report a HUGE boost in their sexual activity. I noticed only a slight boost

- When you're off the cerebrolysine, you feel like it's a bad day for no reason (see above having a top of your game day for no reason lol). I didn't notice any significant negative long-term effects on my cognitive processes. On the contrary I seem to be able to concentrate better at any time, without taking any substances, or even after smoking a lot of weed. I'm now able to "zone in" on something more completely and do better at focusing.

-This stuff has very strong and powerful overall effects, it is the most effective out of injectable nootropics/smart drugs that I've tried. Cortexin doesn't even come close, and various Cerebrolysine derivatives (we ahve a Cerebrolysate here) are nothin more than cheap imitations.

I've decided for another mini-cycle just now, about 3 years after that last lengthy episode. I'm sticking to what the doctors here recommend: 5ml every OTHER day. Seems to be the correct dosage and schedule.

I hope it doesn't sound too much like promo for the Austrian pharmaceuticals company which makes this stuff. It's really not somethin you want to mess around with if you don't know what you're doing.

http://www.longecity.org/forum/topic/28171-cerebrolysin/page__st__30



FASCINATING INFO ON AGING:

THE FOUR CRIMINALS BEHIND AGING: 1. Methylation 2. Oxidation 3. Glycation 4. Inflammation


Glycation, Methylation, Inflammation, Oxidation


Glycation is a chemical process that takes places in the body, which binds sugar and proteins. This binding with sugar makes the structural proteins in your body stiffer and contributes to accelerated aging by reducing flexibility of tissues and organs.

The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases.[8] AGEs have been implicated in Alzheimer's Disease,[9] cardiovascular disease,[10] and stroke.[11] The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis. They form photosensitizers in the crystalline lens, which has implications for cataract development.  Reduced muscle function is also associated with AGEs.

It is not yet clear whether glycation can actually be reversed, however research is currently being conducted on a class of chemicals called AGE breakers. These drugs would theoretically “undo” the damage in glycated tissues, returning them to their normal state.

For all the promise of youth-restoring remedies none has ever reversed the process of aging. Now, for the first time, researchers at Alteon Inc. (alteonpharma.com) have developed a drug that rejuvenates hearts and blood vessels, stiffened with age, by breaking up molecules that cause the trouble.

Anti AGEs

Elusive alt-711 (alagebrium)

Aminoguanidine

NtBHA (Geronova)

N-acetyl-L-carnosine (NALC) (Superior Nutraceuticals)



OTHER NOTES: MDD

Quercetin

Fisetin

Similar to many other flavonoids such as the structurally related flavonol quercetin, fisetin is a potent antioxidant. Its antioxidative activity may be due to its structural properties as well as to its ability to modulate certain cellular signaling pathways, especially protein kinase and lipid kinase pathways. For example, fisetin has been shown to induce the transcription factor Nrf2, leading to increased expression of several protective and antioxidative genes. One study at the Salk Institute found that fisetin may help improve memory and protect the brain from the onset of Alzheimer's disease and also that it may be useful for reducing kidney failure in diabetics.

Side effects Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor. This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.  Fisetin among other flavonoids is suspected to increase risk of infant leukemia (which is rare disease).


Rapamycin
Rapamycin was first shown to extend lifespan in eukaryotes in 2006. Powers et al. showed a dose-responsive effect of rapamycin on lifespan extension in yeast cells. Building on this and other work, in a 2009 study, the lifespans of mice fed rapamycin were increased between 28% and 38% from the beginning of treatment, or 9% to 14% in total increased maximum lifespan. Of particular note, the treatment began in mice aged 20 months, the equivalent of 60 human years. This suggests the possibility of an effective antiaging treatment for humans at an already-advanced age, as opposed to requiring a lifelong regimen beginning in youth. Because it strongly suppresses the immune system, though, people taking rapamycin are more susceptible to dangerous infections. It is not known whether rapamycin will have similar lifespan-lengthening effects in humans, and study authors caution the drug should not be used by the general population for this use until more is known about the substance.

Omega-3 EPA/DHA  http://j.mp/yoYGvO

Furazabol
Furazabol is for cutting, vascularity, weight, cholesterol improvement:  However, recently 100 mg/mL versions have become available. A common dosage can be 10–25 mg/day orally and 25–50 mg daily injected, with optimal results usually seen at 50 mg/day.

Cimaterol
The best choice for weight control and even fat-burning appears to be Cimaterol.  Investigate further.


L-tartrate

Cytomel
There are many advantages to using Cytomel to optimize our metabolic rate. It will also increase your bodys ability to synthesize protein, but from what Ive seen personally, it acts as a catabolic when it isn't administered with anabolic steroids. It is often the last thing added into a pre bodybuilding contest diet as it has a reputation for getting rid of the last few percentages of bodyfat& the "sticky fat" as its called in bodybuilding, the fat that just doesnt want to leave you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a diet to lose fat, as it will optimize your metabolic rate, which should be done at the outset of a diet, not after the calorie restriction has diminished your thyroid output and you are adding it in simply to replace what was lost. Read more: http://www.steroid.com/Cytomel.php#ixzz1iwD2YLl4

Clenbuterol Most users experience a very strong energy rush within 15 minutes of each dose. This characteristic makes it a popular pre-workout intensity pill and thermogenic.  Approximately 8% of users experience a paradoxical effect and become a bit lethargic.



Interesting datum

Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats. http://www.ncbi.nlm.nih.gov/pubmed/22135908

Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Finally, increasing CREB expression after withdrawal from self-administration enhanced cocaine-primed relapse, while reducing CREB levels facilitated extinction of cocaine seeking, but neither altered relapse induced by cocaine cues or footshock stress.

What I've read about Memantine on a large number of internet sites tells me it is believed to work by protecting nerve cells from being killed off by glutamate toxicity. This happens in Alzheimer's when a certain type of receptor on the cells, the NMDA receptor, is over-stimulated by glutamate and releases an overload of calcium into the cell, causing aptosis / excitotoxicity. Memantine regulates the calcium ion inflow by partially blocking the NMDA receptor. Although memantine is a patented prescription NMDA blocker, so too are a number of non-prescription nutriceuticals.  Among them are: Huperzine-A, which aside from its primary action as a a cholinesterase inhibitor will also protect the brain from glutamate excitotoxicity.  Theanine, is a derivative of green tea, and a potent DA producer (I do not believe this is via a conversion into L-Dopa, then Dopamine, much the way many Alzheimers drugs work, rather I think it sponsors a spike in endogenous production of the DA neurotransmitter) also.  L-theanine has a paradoxical relaxing effect and is believed to be the agent that counters the stimulating and sometimes anxiety producing effects of caffeine contained in most green teas.  L-theanine typically has anxiolytic and mood-elevating effects without drowsiness.


Vitamin E and the methylcobalamin form of B12 are effective neuroprotectants.  The Lithium info I found recently, and it is being considered for Alzheimer's trials. As it's available in safe supplement form as lithium orotate, I give her that also, (one capsule daily) and it does seem to be giving her an extra improvement in mood, and she has a good sense of humour, often with fits of giggles! I read about the effects of Lithium orotate at a number of sites. It should be stressed that this only applies to the orotate form of lithium, which is non-prescription yet still effective at stabillizing mood.

Should investigate OPCs.  Basically they're polyphenols, principally Proanthocyanidin.  The group are powerful antioxidants that have recently been stabilized and made bioavailable.

Galantamine used with choline bitartrate or Alpha-GPC Galantamine has been used as a neuroprotectant and sleep aid, Galantamine can help people fall asleep and also increase sleep-stage quality.

Dopamine types: D1 dysphoric D2 euphoric

7-amino-8-hydroxbutyric acid (GABOB) worth researching. Nutraplanet might be getting it. For it to have ghb effects it has to be injected.No thanks are there any benifits taking orally? Not that I see ! I wish ghb could be illegal by us responsible folks.

chocamine+deprenyl+inositol+bacopa+sam-E I take 1 gram of theanine, 1 gram of Green Tea, Fish Oil, and two amp.


Hydrocodone (or codeine) + Carisoprodol.

Piractem, Sulbutamaine, choline

Cytolean by Gaspari is pretty smooth



Sci-Vi Dianle 4



Stim X is too much



Tryosine is always nice



Smart drugs-Piractem, Sulbutamaine, choline





Methylphenidate (I.V, snorted or oral, your choise)

+ Ma-huang (oral) and or Sida cordifolia (oral) / Or ephedrine HCL

+ Nicotine (snorted, smoked, oral, or dermal)

+ Caffeine (snorted or oral)



Optional ad on

+ Tyrosine (oral)

+ ALCAR (oral)

+ (K)-R-ALA (oral)

+ some cayenne/chili/natrium bicarbonate for absortion



This combination in the right dosages gives a warm and pleasant feeling, tremendous euphoria (like MDMA) and a lot more self esthem (like coke)





Yeah, xanax + tramadol is some good times. First time I mixed tramadol with some KB it made things a bit too much. Like verging on bad trip too much. But I had about 400mg tramadol in my system and MJ tends to give me the fear anyway these days. (which is fine as it fucks with my concentration for days afterwards. Better off without it.)



Also bump on the hydro plus muscle relaxers. I only had access to flexeril, but man, I felt like Homer Simpson going off into sleepland, where the moon winks at him and the clouds turn into beds. Ahhhhh.


I really need to give tramadol a shot.

cocaethylene













"There are no shortcuts to any place worth going.


One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.




Give Stimulant X from AX a shot, everyonez talkin abt it  ... and its free

XCeed is a CEE with some other boosters - nothing that looks like a stim. to me.

yerba mate wisdom of the ancients vanilla yerba mate and guayaki's

PW could definitely help out. Cordygen5 and Citruvol would be a great combination, also. It would help improve endurance, strength, oxygen utilization, ATP production, recovery, etc. In turn, it could make for an easier work day

Thermolife Stizm. WOW. this is my all time fave



Centrophenoxine 500 mg 60 caps


Pyritinol 400 mg 60 caps


Alpha GPC 300 mg 60 caps


CDP Choline 250 mg 60 capsules


DMAE Bitartrate 150 mg 200 capsules


Acetyl-L-Carnitine 500 mg 100 capsules


Aniracetam 750 mg 60 capsules


Idebenone 180 mg 60 caps


Super Ginkgo Extract 28/7 120 mg 100 caps


























Supplements:


Pramiracetam

Hydergine

Phenibut

Idebenone

Roxindole

Phenylpiracetam Carphedon' or 'Phenotropil So I have tried a bunch of legal and quasi-legal stims, all with disappointing results (ephedrine, caffeine, 1-3-dimethylamylamine, BZP, etc.) But the other day I found a website selling phenylpiracetam. This is more well known as 'Carphedon' or 'Phenotropil' - an obscure Russian stimulant developed to keep astronauts awake on long missions, and occasionally used in Russia as a prescription nootropic for various types of neurological disease. It became well known a couple years ago when a bunch of athletes got kicked out of the Olympics for using it, leading a nootropic supplier in California to start selling it on the Internet as a supplement.

http://www.tradekey.com/index.html?action=buyoffer_manage&track=success&msg=Your%20buy%20offer%20has%20been%20posted%20successfully!%20It%20will%20be%20available%20for%20display%20in%20some%20time&source=buyoffer&keyword=Carphedon,%20Phenotropil,%20Phenylpiracetam%20&sendemail=1

Adapton Iherb.com

"Depressant" and "euphoriant" are distinct is because we have classes of drugs that can fairly selectively achieve either one or the other effect. Confounding the issue, we also have classes of drugs which may produce both euphoria and an antidepressant effect, ie Parnate, Nardil, Amineptine, ketamine, certain cannabanoids, and possably the opiates etc.


INCREDIBLE POST:

POSTED ON: In reply to Re: Vicodin and Percocet for Depression » linkadge, posted by Quintal on August 15, 2007, at 0:32:15 http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20070815/msgs/776511.html


17) Morphine, a mood brigtening smart drug http://opioids.com/cogmood/morphine.html 18) Case studies, long term relief of depression in highly refractory cases with fixed doses of oxycodone. http://opioids.com/antidepressant/opiate.html 19) Use of opiates in highly refractory AD and ECT nonresponse. http://opioids.com/antidepressant/opiates.html 20) The DST and as predictor of response to opiates. http://opioids.com/antidepressant/depression-subtypes.html 21) Methadone and morphine in depression http://opioids.com/antidepressant/index.html 22) The antdepressant effect of endomorphins. http://opioids.com/endomorphins/antidepressant.html

http://www.druglibrary.org/Schaffer/heroin/methadone/toxicity.htm

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=substance+P+inhibitors#hl=en&expIds=17259,17315,18167,20782,23628,23670,23945,25646,25834,25907,26328,26637,26746,26761,26849,27000&sugexp=ldymls&xhr=t&q=substance+P+produce+euphoria&cp=28&pf=p&sclient=psy&safe=off&aq=f&aqi=&aql=&oq=substance+P+produce+euphoria&gs_rfai=&pbx=1&fp=8d771dec467097a5

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=PEPTIDE+TRANSMITTERS:+A+UNIFYING+HYPOTHESIS+FOR+EUPHORIA,+RESPIRATION,+SLEEP,+AND+THE+ACTION+OF+LITHIUM

http://www.dr-bob.org/babble/alter/



Possible new stimulants / euphoriants / and pro-social substances and compounds:

"Substance P"

NK1 receptor antagonist or inhibitor significant increase in dopamine secretion into the nucleus accumbens

These data attest to the reinforcing characteristics of an enkephalin analog

Natural polypeptides may contribute to the reinforcing properties of opiate drugs.

Acute administration of short-acting opiates in animal models causes a reduction in FSH and LH levels, a reduction in glucocorticoid levels, and an increase in prolactin levels. In studies of methadone-maintained patients, several workers have found that plasma levels of FSH and LH may be significantly reduced in some patients during the first year of chronic treatment (Table 7). In both prospective and special studies, it has been shown that levels of these hormones returned to normal after two or more years of chronic methadone treatment. However, we have found that testosterone may remain decreased in around 20-30% of patients after one year of chronic treatment.

It has been well-documented that the acute or subacute administration of narcotics to humans results in a predictable significant reduction in plasma cortisol levels, presumably reflecting a reduction in ACTH levels. It has also been shown that during cycles of subacute or chronic morphine administration in former heroin addicts, both cortisol levels and total urinary excretion of glucocorticoids are reduced. However, our group and others have shown that during chronic long-term methadone administration, plasma cortisol levels are within normal range with a brisk but normal circadian variation.7, 88, 25, 37 In recent studies to be discussed in more detail, we have also shown that plasma levels of ACTH are normal in patients during chronic long-term methadone maintenance treatment.37 In early studies reported in 1972 and 1974, we have found that during the first 2 months of chronic methadone treatment, significant alterations of function of the hypothalamic-pituitary adrenal axis do exist, as evidenced by abnormal metyrapone test results, indicating reduced hypothalamic-pituitary reserve for release of tropic hormones.8, 25 We showed that tolerance develops to this effect after three or more months of stabilized methadone treatment.



























































































ANTI AGING DOCTOR LIST BELOW:

REGIMEN:
PQQ (pyrroloquinoline quinone) 50mg's/day Aniracetam 750 mg each /4X/day Centrophenoxine 500 mg 4/day x 4 days on, 4 days off Acetyl-L-Carnitine 500 mg / 3 - 4 per day (high dose) DMAE Bitartrate 150 mg / 3 per day Alpha GPC 300 mg each / 2 per day Omega-3 EPA/DHA  2x day http://j.mp/yoYGvO http://j.mp/slash-risk-of-premature-death-85-percent 5-MTHF 50mg / 1X day Pyritinol 400 mg each / 1 per day CDP Choline 250 mg / 2 per day Idebenone 180mg  / 1 - 2 per day Life Extension Super Ginkgo 120mg / 2 day Ubiquinol Benfotiamine Rhodiola
Phosphatidylserine  http://j.mp/zGl4hK S-adenosylmethionine http://j.mp/Aisb71


Interesting pharma or RC ("research chemical"):

Prolintane aka Catovit

1-(thien-2-yl)isopropylamine

Butylone


Interesting Nootropic: Rolipram (http://j.mp/rolipram)

CX717
“It generates a state of cortical wakefulness without stimulation,” says Gary Lynch at the University of California at Irvine, who invented ampakines. Cortex Pharmaceuticals Inc., based in Irvine, California

Ampakines work by binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. And because of their short half-life - hours in this case - ampakines have few side effects.

Rasagiline & Selegiline By inhibiting MAO-B, rasagiline prevents the deamination of the monoamines dopamine and phenethylamine (PEA), thereby increasing their concentration in the synapse and curbing production of the reactive oxygen species, hydrogen peroxide. High concentrations of hydrogen peroxide are associated with increased oxidative stress. Rasagiline both raises levels of striatal dopamine produced from levodopa and improves the survival prospects of ailing dopaminergic neurons themselves. This salvage job helps restore a measure of normal locomotion, gait and coordination in Parkinsonian patients while delaying their physical decline.

Both selegiline and rasagiline are neuroprotective via multiple mechanisms that are poorly understood. However, their role in stabilising mitochondrial membrane potential is critical. The propargylamine moiety rather than MAO inhibition per se apparently holds the key to their neuroprotective action: the S isomer of rasagiline is some 1000 times less potent as an MAO inhibitor, but it's still protective against neurotoxic insults. Rasagiline inhibits activation of the apoptotic cascade triggered by dopamine neurotoxins and oxidative stress. Apoptosis is an active process of programmed cell-death induced by exposure to neurotoxins. Rasagiline and other propargylamines can rescue deteriorating dopaminergic neurons by inhibiting the "death signal" transduction-mechanism of mitochondrial permeability transition. Current evidence suggests that rasagiline may be more effective than selegiline in salvaging dopamine nerve cells from the usual neurological carnage of later life.


Two fascinating Russian chems and experience reports:

Cerebrolysin It's the second day I take cerebrolysin only. The effect is very interesting, I wake up very energetic, my sensitivity to caffeine has increased a lot. A cup of espresso is too much for me.

Cerebrolysin appears to have some kind of antidepressant / anti-anxiety effect. I have never used anxiolytics or antidepressants before but I noticed that I don't feel depressed or anxious under extremely stressful situations. I had trouble getting asleep as well, but now I just go to my bed and I get asleep in 10-15 mins.

Cerebrolysin probably does not have a typical antidepressant / anxiolytic affect. I guess that you can only notice the effect of cerebrolysin if you have to undergo extremely high workload, stressful situations... I simply don't get tired and I can relax much easier after any stressful event

This nootropic is one of those which have a very pronounced effect and it scares me  To be honest, it is one of the reasons I will not continue taking cerebrolysin. Nobody knows what are the long term effects of this drug. I am a healthy individual, so I don't see any need to take a risk and use it any longer. However it was a positive experience


Phenotropil works wonders when I take it with Semax.

The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"

It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.

Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.

As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.

I hope this is useful to everyone interested in this peptide.


Fascinating Nootropic and notes + list:

Noopept.

1010pharma.com is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax right now, anti-aging.com may carry...

One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

http://www.apteka-dr...erc-3ml-n1.aspx

phenylpiracetam

http://www.backtone.com/

N-PEP-12(MemoProve) which is a derivative of Cerebrolysin

Memantine - Namenda

Alpha GPC

Selegiline - Deprenyl

Horny goat weed - Same as above. PDE5 inhibition could be helpful as well on occasion (those first couple hours of amphetamine are brutal).

Agmatine - It's an obscure possible neurotransmitter produced from arginine that among many possible benefits blocks NMDA receptors and thus hopefully helps mitigate amphetamine tolerance. It may improve mood, memory, and sleep as well.

Phenibut, while I loved the initial effects, became detrimental VERY FAST (depressant action). So 2-3 times a week seems too much to me. Just be aware of this.

Huperzine A - NMDA. Hopefully some memory improvement. I've read that this may be dangerous to take regularly so I will probably go with 200mcg every other day. If taking any of these drugs for depression, be very careful with Huperzine A.

Green tea extract - It's high in ECGC. Good anti-oxidant. I will likely take this daily.

Bacopa - I took it regularly for about three weeks, one dose in the evening. It can make you a bit drowsy.

Magnesium Glycinate - best form of magnesium to take.

L-Theanine - Fantastic DA augmentor.

Sulbutiamine 300mg -Sulbutiamine is a funny substance. It's amazing at first. Many have noticed it decreases creativity to an extent, which I would tend to agree with. But it should also be used very sparingly-- tolerance will develop. Because of the receptors it antagonizes/agonizes, its effects are much more pronounced with caffeine. I.e., it is synergistic.

Interesting nutra to consider taking or taking more regularly: DL-Phenylalanine Yohimbe
L-Tyrosine Copper Gluconate Choline Bitartrate Dicalcium Phosphate 120 MG L-Potassium Aspartate 30 MG Propionyl-L-Carnitine 1000 MG L-Asparagine 650 MG Acetyl-L-Carnitine 500 MG L-Potassium Aspartate 150 MG Caffeine (USP) 125 MG L-Tyrosine: 1800mg Acetyl L-Carnitine: 500mg Sulbutiamine: 300mg Rhodiola Rosea: 200mg -(standardized to 3%) Vinpocetine: 20mg Pyrodoxine HCL: 8mg

Camellia Sinensis 60% Polyphenols (green leaves), Yohimbine Alkaloids (pausinystalia yohimbe bark), 6’ 7’-Dihydroxybergamottin (fruit), Camellia Sinensis 60% Polyphenols (white leaves), Capsaicin (fruit)

Stimulant X www.stimulantx.com

Most frequently prescribed MAOIs include Nardil, Parnate, and Elderpril.

Nicotinic analogues

Gotu Kola - claim that oldest man who ever lived (chinese dude claimed to be over 200 years old) was taking tons of this stuff.

Take CEE and some adaptogens

AMP or Focus XT for a neural boost

Panax ginseng

Palatinose + extra citrulline malate + extra beta alanine + ALCAR + Tyrosine synergy

Maca - traded as currency amongst spanish colonials once

Ergopharm's amp...stimx, pumpjuice2.0 (not just a stim).

Glucuronolactone

XCeed is a CEE

Yerba mate

PW could definitely help out. Cordygen5 and Citruvo: Improves endurance, strength, oxygen efficiency, ATP production

Thermolife Stizm. WOW excellent reviews

Metformin
The mechanisms for lifespan extension by metformin are not completely understood yet but probably involve AMPK and its downstream target mTOR (fig. 1) (4). mTOR is also the target of the famous life extension drug rapamycin that increases lifespan in mice both when administered early and during middle life (15,16). mTOR inhibits autophagy thus metformin activates autophagy by inhibiting mTOR. Autophagy clears cells from dysfunctional organelles – such as mitochondria – and other junk that can impair normal cellular functions and thereby extends lifespan. mTOR stimulates protein synthesis and for still very incomplete understood reasons protein synthesis reduces lifespan. Therefore again metformin is expected to retard aging. If the cell cycle is arrested – that is the cell temporally stops dividing – and the cell continues to receive growth signals (mTOR stays active), it can lead to cell senescence – a state of permanent cell cycle arrest (4). Senescent cells secrete proinflammatory molecules, this has been termed the senescence-associated secretory phenotype, and can locally stimulate tumor growth (17). Metformin is expected to prevent cell senescence by removing the growth signal pressure. AMPK inhibits NAD(P)H oxidase, an enzyme whose action produces superoxide – a free radical. Metformin thus decreases free radical production (4). Free radicals are molecules that have an unpaired electron, they desperately try to find an extra electron to stabilize their configuration and in the process destroy other molecules by stealing their electrons. The free radical theory of aging is without doubt the most well known mechanistic aging theory. It was first proposed by Denham Harman in 1956 (18). Since then the failure of antioxidants to extend the lifespan has cast doubt on the validity of the free radical theory but still most biogerontologists think that free radicals do play a certain role. In fact some even suggest that the failure of antioxidants is expected because they undermine the bodies stress response (19). AMPK can be activated by: (i) binding of AMP, and (ii) phosphorylation by other enzymes. Metformin has clearly been shown to increase the phosphorylation of AMPK but the effects on AMP are disputed. Phenformin and buformin inhibits complex I of the respiratory chain, so maybe metformin does so too. Such an inhibition would decrease ATP – the universal energy currency for life – production and thereby increase AMP levels.

Phenylpiracetam, Phenotropil, Fenotropil, Carphedon

Fenotropil has a positive effect on metabolism and blood circulation within the brain. It stimulates the Redox processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in Ischemic areas of the brain. Moreover, it increases noradrenaline, dopamine, and serotonin brain levels. It does not affect GABA levels and is not associated with GABA A- and -B receptors. It produces no significant effect on spontaneous brain activity.

Fenotropil has no effect on the respiratory and cardiovascular systems. However, it produces a mild diuretic effect and anorexic activity in the exchange application.

Fenotropil provides a moderately stimulating effect on motor responses and improves physical performance. The moderate awareness-inducing effect of the drug is combined with anxiolytic activity. Fenotropil improves mood and has analgesic effects, increasing the pain threshold. Additionally, it has an adaptogenic effect, increasing the organism's resistance to stress in conditions of increased mental and physical stress and fatigue. Furthermore, it increases resistance to freezing hypokinesia.

With the advent of Phenotropil, marked improvements were noted in vision (an increase in sharpness, brightness, and field of view). Fenotropil improves blood flow to the lower extremities. Fenotropil stimulates the production of antibodies in response to the antigen, indicating that it has immunostimulator properties but at the same time does not cause the development of immediate hypersensitivity reactions and does not alter the allergic inflammatory reaction of the skin caused by the introduction of foreign proteins. In the exchange application, Phenotropil does not develop drug dependence and tolerance. The drug is not marked in the development of withdrawal syndrome.

Actions of Fenotropil are seen after a single application, which is important when the drug is used in extreme conditions. Phenotropil significantly enhances the action of other Nootropic drugs.

Fenotropil is not metabolized in the body and excreted, unchanged in form. About 40% is excreted in the urine and 60% in bile and sweat. The half-life is 3-5 hours. The average single dose is 150 mg (100-250 mg); the average daily dose is 250 mg (200-300 mg). The maximum daily dose is 750 mg. The multiplicity of reception is 1-2 times a day. A daily dose of 100 mg can be taken one time a day (morning), while doses exceeding 100 mg should be taken in two doses. The duration of treatment ranges from two weeks to three months. The average course of treatment is 30 days.



RECREATIONAL SUBSTANCES WORTH RESEARCHING:

Dimoxamine

DOM

2C-I

2C-I and 2-CT-2

2C-I (2,5-dimethoxy-4-iodophenethylamine) Most likely candidate for the coveted title "the next ecstasy".

http://medi.ru/doc/3101.htm http://www.phenotropil.ru/pub/ kunwha.com


Cerebrolysin has to be injected intravenously or intramuscularly. It cannot be injected into the fatty tissue. An intramuscular (IM) injection is a shot where the needle goes into the muscle layer under the skin to deliver medicine. IM injections are deeper than subcutaneous injections (given under the skin). Parts of the Body Involved - Upper arm, Top of the thigh, Buttocks (most common and recommended for 5 ml cerebrolysin injections).

A needle passes through skin and fat layers into the muscle fibers to deliver medicine.

http://www.longecity.org/forum/topic/28171-cerebrolysin/


NOTES:

I have a few questions if you wouldn't mind answering them?

1) How long did you use it for? I beleive there's five 5 ml ampoules in each packet. It sounds like you took 5 ml (first day), 5 ml (2nd day), 10 ml (3rd day), then possibly 5 ml the 5th day if you used all the ampoules up?

2) Dosaging Instructions According to Antiaging-Systems: The normal dosage pattern seems to be to do an injection 5 days out of a 7 day week for 4 weeks. Alzheimers patients (or possibly certain people suffering a delay of some sort to a lesser severity) would take 1 ml, 5 ml, or 10 ml ampoules once a day Mon.-Fri. (or whatever's 5 days; skipping 2 days each week) for 4 weeks (before waiting 3 months to begin again). The benefits are supposed to last possibly up to 3-6 months.

With that being said, 10 ml seems like it could potentially be a bit much for a healthy person to take. Did you notice a direct difference between the 5 ml on the 1st day vs. the last day? Or the 5 ml (from the 1st and last day) vs. the 10 ml?

3) Any dizziness, headache, or heat sensations? According to http://www.antiaging...erebrolysin.htm these are some rarer side-effects that may occur if administered too quickly? (meaning possibly jumping right up to 10 ml could of been done too quickly?)

4) It doesn't appear side-effects are common. Perhaps a healthy person could order 10 1 ml ampoules (this is much cheaper for around $50) instead of the 5 5ml (around $70) or 5 10ml (around $90). This would mean for $100 someone could do the 4 week program using only 1 ml ampoules instead of paying around $280 for a 4 week program using 5 ml ampoules.

5) I don't want to throw this thread off track here but have you heard of "Cortexinum"?http://www.pharmacy1...age.asp?id=1375 It seems surprisingly similar to Cerebrolysin. I'm wondering if this is some sort of Russian variant brand of Cerebrolysin?


I will post this again:

There are no Cerebrolysin alternatives which can be taken orally except N-PEP-12(MemoProve) which is a derivative of Cerebrolysin and it is much less potent.

Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com


1) I had 2 packs of cerebrolysin. I used 5 ml for the first 3 days and 10 for ml for 2 days.

2) I did not notice anything for the first 2 days. The effect became really noticeable on the 3rd day, even more noticeable on 4th and 5th. Btw, 1 ml ampules are usually given to kids.

3) I did not feel any dizziness, headache, or heat sensations. Those side effects usually occur when you inject a cold liquid intravenously. To avoid this it has to be warm enough (room temperature) and you have to inject it slowly.

4) 1 ml is a very small dose, it is not enough even for a healthy adult. I have read the instructions and it says that doses of 1-2 ml are given to kids. Doses up to 50 ml (IV) can be given in severe cases. Cerebrolysin is overpriced if you buy it online. I bought another pack of cerebrolysin while traveling in one of the EU countries, the price at the pharmacy was 34 USD (5 x 5ml amp)

5) If I remember correctly cortexin is made from cattle brain. I will try to get some more info about it. Edited by anony4mous, 22 April 2009 - 01:32 AM.



Cortexin peptide drug is largely similar to the cerebrolysin, used also by intramuscular injection./Pharmacological Effects: The drug improves cerebral metabolism. Cortexin represents liofilizat obtained by acetate extract from the bark of the brain of cattle or pigs, which contains low-molecular active neuropeptides, the molecular weight of not more than 10 000 dalton, sufficient to penetrate through hematoencephalic barrier./Cortexin has a unique multi-effects on the brain, as demonstrated in metabolic regulation, neuropatronage, functional neuromodulation, neurotrophic activity. Cortexin improves the efficiency of energy metabolism of brain cells, improves the intracellular synthesis of protein, regulates the processes of oxidation of lipids in cells of the brain reduces the formation of free radicals, blocking the processes of free-radical oxidation. The product eliminates the imbalance of braking and excitatory amino acids, has a moderate GABA-ergic action./The drug has a positive effect in violation of cognitive function, improves concentration, short-term memory, learning ability, accelerates the recovery of the functions of the brain after stress effects, regulates the levels of serotonin and dopamine. It stimulates the process of mental activity, not providing excessive activation of influence, restores bioelectric activity of the brain, stimulates the reparative processes in the brain./Indications for use: Violations of the cerebral circulation; encephalopathy of different genesis, acute and chronic encephalitis and encephalomyelitis, epilepsy, brain trauma, viral and bacterial neuroinfection; infantile cerebral palsy, delayed psychomotor and speech development in children; asthenia, memory, thinking, reducing the ability to learn.


Concentrate always means - impure. Hydrolyate means a more exact synthesis of adding hydrogen to the the purified mix. Both kinda suck, because all you want is the chemical, but what the process gives you, is impurities. The more you get rid of that - the higher the costs get.

I was taking up to 10 ml of cerebrolysine daily at work though I/M injections, easily for a good 6 months if not more. (Usually in 2 injections, although I've shot 10ml straight up before in one large syringe) Since I worked in 4-day shifts, I'd usually go 4 days on and then 4 days off to cool off my neurons  That easily allowed me to handle all the stresses, and I was one of the best at that particular job. Despite having abused illegal drugs in the past and being a frequent cannabis smoker, I experienced little to no "stoner burnout" and was able to concentrate and perform tasks faster than most of my colleagues at the same experience level. After a long 12-hour work day, after which a normal brain turns to mush, I was still fresh and eager to go out with friends/ see girls etc, while otherwise I'd be drained and only wanting to sleep.


So instead of rambling on further, let me just break down some effects and side-effects, short and long term:

-This stuff has a MARKED anti-depressant effect. You basically feel like back in the happiest moments of your childhood. Everyone has had one of those days when they're just "on fire" and "on top of the game". With Cerebrolysine, pretty much every day is like that - you're not overly happy or vegetated like off standard anti-depressants, but you're "on point" at whatever you do. Stuff like your subconscious and conscious fears all go right out of the window, and it has a bit of a socially-inhibiting effect too.

-If you thought weed gets you the munchies, wait till you try this stuff. When you first start on this cycle, you get hungry as a SAVAGE. I usually eat just enough to be full, not overly gorged, but this stuff had me tearing up huge meals and not even feeling incapacitated by everything I just ate. I'd attribute this to the fact that with all the additional peptides and stuff, your body needs more nutrition. Sort of like adding B-vitamins to stuff like Pyritinol or even good old 5-HTP.

-Cerebrolysine helps alleviate most, if not all symptoms of post-intoxication syndrome for illicit drugs. I once gave my friend a shot after his most recent cocaine binge and he turned from a pale shadow who was about to pass out back to his normal self - energetic, enthusiastic, and motivated. Plus his foul mood and edginess were completely gone. It also seems to ease the alcohol-related hangover better than some other substances (although many nootropics are much better for that IMO since they're GABA-active). My other friend also liked taking it as a "corrector agent" for other nootropics/supplements, claiming it helped alleviate certain unwanted effects of piracetam, while preventing one from overloading on one particular amino acid too much. I personally avoid ALL other substances when doing cerebrolysine. It simply overshadows them all for me.

-They definitely put some kind of a painkiller in there. Shooting cortexin (which is similar, but I like it alot less, as it "vegetates" and sedates me too much to where I'm more mentally capable, but simply don't care) without a novacaine solution is literally a huge pain in the rear, while shooting straight cerebrolysine into my tiny tricep with a huge needle made my whole arm go numb for a short time, like an anastetic would.

-I've measured my blood pressure several times before and after the injections, and there is a slight blood pressure elevation. If you inject too fast, the heart rate jumps and you may sweat profusely. However it gives you a nice sort of a "rush" to where you feel very relaxed, but not incapacitated or drugged by any stretch of imagination. The headaches are there, but are very slight, and usually start about 2-3 hours after the injection.

-The long-term effects aren't so pleasant. There is an increasing feeling of "mounting personal hell" as I like to call it. Basically, all the negative traits of one's character seem to be unnaturally emphasized and underlined in your mind, while the positives seem little and insignificant. It doesn't really manifest itself in a severe form to others, but you may feel "grumpy" and "dissatisfied" even when you seem to be razor-sharp mentally. A good comparision would be some rich spoiled kid who has everything throwing tantrums and breaking stuff, just because he is rich and spoiled. Several of my friends reported very similar mental side effects. This is what initially led me to stop taking it by "tapering down" (I don't think it's a good method by the way, but since I was doin it daily for a while I decided for a slower descent). A .5 ml less every day for several days, then a week at 1ml and then 0.5 and then you're shooting colored water for placebo effects

- Some people report a HUGE boost in their sexual activity. I noticed only a slight boost

- When you're off the cerebrolysine, you feel like it's a bad day for no reason (see above having a top of your game day for no reason lol). I didn't notice any significant negative long-term effects on my cognitive processes. On the contrary I seem to be able to concentrate better at any time, without taking any substances, or even after smoking a lot of weed. I'm now able to "zone in" on something more completely and do better at focusing.

-This stuff has very strong and powerful overall effects, it is the most effective out of injectable nootropics/smart drugs that I've tried. Cortexin doesn't even come close, and various Cerebrolysine derivatives (we ahve a Cerebrolysate here) are nothin more than cheap imitations.

I've decided for another mini-cycle just now, about 3 years after that last lengthy episode. I'm sticking to what the doctors here recommend: 5ml every OTHER day. Seems to be the correct dosage and schedule.

I hope it doesn't sound too much like promo for the Austrian pharmaceuticals company which makes this stuff. It's really not somethin you want to mess around with if you don't know what you're doing.

http://www.longecity.org/forum/topic/28171-cerebrolysin/page__st__30



FASCINATING INFO ON AGING:

THE FOUR CRIMINALS BEHIND AGING: 1. Methylation 2. Oxidation 3. Glycation 4. Inflammation


Glycation, Methylation, Inflammation, Oxidation


Glycation is a chemical process that takes places in the body, which binds sugar and proteins. This binding with sugar makes the structural proteins in your body stiffer and contributes to accelerated aging by reducing flexibility of tissues and organs.

The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases.[8] AGEs have been implicated in Alzheimer's Disease,[9] cardiovascular disease,[10] and stroke.[11] The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis. They form photosensitizers in the crystalline lens, which has implications for cataract development.  Reduced muscle function is also associated with AGEs.

It is not yet clear whether glycation can actually be reversed, however research is currently being conducted on a class of chemicals called AGE breakers. These drugs would theoretically “undo” the damage in glycated tissues, returning them to their normal state.

For all the promise of youth-restoring remedies none has ever reversed the process of aging. Now, for the first time, researchers at Alteon Inc. (alteonpharma.com) have developed a drug that rejuvenates hearts and blood vessels, stiffened with age, by breaking up molecules that cause the trouble.

Anti AGEs

Elusive alt-711 (alagebrium)

Aminoguanidine

NtBHA (Geronova)

N-acetyl-L-carnosine (NALC) (Superior Nutraceuticals)



OTHER NOTES: MDD

Quercetin

Fisetin

Similar to many other flavonoids such as the structurally related flavonol quercetin, fisetin is a potent antioxidant. Its antioxidative activity may be due to its structural properties as well as to its ability to modulate certain cellular signaling pathways, especially protein kinase and lipid kinase pathways. For example, fisetin has been shown to induce the transcription factor Nrf2, leading to increased expression of several protective and antioxidative genes. One study at the Salk Institute found that fisetin may help improve memory and protect the brain from the onset of Alzheimer's disease and also that it may be useful for reducing kidney failure in diabetics.

Side effects Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor. This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.  Fisetin among other flavonoids is suspected to increase risk of infant leukemia (which is rare disease).


Rapamycin
Rapamycin was first shown to extend lifespan in eukaryotes in 2006. Powers et al. showed a dose-responsive effect of rapamycin on lifespan extension in yeast cells. Building on this and other work, in a 2009 study, the lifespans of mice fed rapamycin were increased between 28% and 38% from the beginning of treatment, or 9% to 14% in total increased maximum lifespan. Of particular note, the treatment began in mice aged 20 months, the equivalent of 60 human years. This suggests the possibility of an effective antiaging treatment for humans at an already-advanced age, as opposed to requiring a lifelong regimen beginning in youth. Because it strongly suppresses the immune system, though, people taking rapamycin are more susceptible to dangerous infections. It is not known whether rapamycin will have similar lifespan-lengthening effects in humans, and study authors caution the drug should not be used by the general population for this use until more is known about the substance.

Omega-3 EPA/DHA  http://j.mp/yoYGvO

Furazabol
Furazabol is for cutting, vascularity, weight, cholesterol improvement:  However, recently 100 mg/mL versions have become available. A common dosage can be 10–25 mg/day orally and 25–50 mg daily injected, with optimal results usually seen at 50 mg/day.

Cimaterol
The best choice for weight control and even fat-burning appears to be Cimaterol.  Investigate further.


L-tartrate

Cytomel
There are many advantages to using Cytomel to optimize our metabolic rate. It will also increase your bodys ability to synthesize protein, but from what Ive seen personally, it acts as a catabolic when it isn't administered with anabolic steroids. It is often the last thing added into a pre bodybuilding contest diet as it has a reputation for getting rid of the last few percentages of bodyfat& the "sticky fat" as its called in bodybuilding, the fat that just doesnt want to leave you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a diet to lose fat, as it will optimize your metabolic rate, which should be done at the outset of a diet, not after the calorie restriction has diminished your thyroid output and you are adding it in simply to replace what was lost. Read more: http://www.steroid.com/Cytomel.php#ixzz1iwD2YLl4

Clenbuterol Most users experience a very strong energy rush within 15 minutes of each dose. This characteristic makes it a popular pre-workout intensity pill and thermogenic.  Approximately 8% of users experience a paradoxical effect and become a bit lethargic.



Interesting datum

Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats. http://www.ncbi.nlm.nih.gov/pubmed/22135908

Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Finally, increasing CREB expression after withdrawal from self-administration enhanced cocaine-primed relapse, while reducing CREB levels facilitated extinction of cocaine seeking, but neither altered relapse induced by cocaine cues or footshock stress.

What I've read about Memantine on a large number of internet sites tells me it is believed to work by protecting nerve cells from being killed off by glutamate toxicity. This happens in Alzheimer's when a certain type of receptor on the cells, the NMDA receptor, is over-stimulated by glutamate and releases an overload of calcium into the cell, causing aptosis / excitotoxicity. Memantine regulates the calcium ion inflow by partially blocking the NMDA receptor. Although memantine is a patented prescription NMDA blocker, so too are a number of non-prescription nutriceuticals.  Among them are: Huperzine-A, which aside from its primary action as a a cholinesterase inhibitor will also protect the brain from glutamate excitotoxicity.  Theanine, is a derivative of green tea, and a potent DA producer (I do not believe this is via a conversion into L-Dopa, then Dopamine, much the way many Alzheimers drugs work, rather I think it sponsors a spike in endogenous production of the DA neurotransmitter) also.  L-theanine has a paradoxical relaxing effect and is believed to be the agent that counters the stimulating and sometimes anxiety producing effects of caffeine contained in most green teas.  L-theanine typically has anxiolytic and mood-elevating effects without drowsiness.


Vitamin E and the methylcobalamin form of B12 are effective neuroprotectants.  The Lithium info I found recently, and it is being considered for Alzheimer's trials. As it's available in safe supplement form as lithium orotate, I give her that also, (one capsule daily) and it does seem to be giving her an extra improvement in mood, and she has a good sense of humour, often with fits of giggles! I read about the effects of Lithium orotate at a number of sites. It should be stressed that this only applies to the orotate form of lithium, which is non-prescription and yet still effective at stabillizing mood.


Have you ever considered adding OPCs? They are a super powered antioxidant that oxygenate the blood. This gets more oxygen to all parts of the body, especially the brain. You can look up OPCs on websites or email me for more info.


Galantamine used with choline bitartrate or Alpha-GPC Galantamine has been used as a sleep aid, Galantamine has been anecdotally described both to help people fall asleep and increasing the quality of sleep once someone falls asleep. Extensive research and sleep studies have not been conducted, but initial microbiological research suggests that Galantamine does have properties that can aid patients suffering from insomnia.

D1 dysphoric D2 euphoric


Guys you might like this one 7-amino-8-hydroxbutyric acid (GABOB) Google it. Nutraplanet might be getting it. For it to have ghb effects it has to be injected.No thanks are there any benifits taking orally? Not that I see ! I wish ghb could be illegal by us responsible folks.

chocamine+deprenyl+inositol+bacopa+sam-E I take 1 gram of theanine, 1 gram of Green Tea, Fish Oil, and two amp.


Hydrocodone (or codeine) + Carisoprodol.

Piractem, Sulbutamaine, choline

Cytolean by Gaspari is pretty smooth



Sci-Vi Dianle 4



Stim X is too much



Tryosine is always nice



Smart drugs-Piractem, Sulbutamaine, choline





Methylphenidate (I.V, snorted or oral, your choise)

+ Ma-huang (oral) and or Sida cordifolia (oral) / Or ephedrine HCL

+ Nicotine (snorted, smoked, oral, or dermal)

+ Caffeine (snorted or oral)



Optional ad on

+ Tyrosine (oral)

+ ALCAR (oral)

+ (K)-R-ALA (oral)

+ some cayenne/chili/natrium bicarbonate for absortion



This combination in the right dosages gives a warm and pleasant feeling, tremendous euphoria (like MDMA) and a lot more self esthem (like coke)





Yeah, xanax + tramadol is some good times. First time I mixed tramadol with some KB it made things a bit too much. Like verging on bad trip too much. But I had about 400mg tramadol in my system and MJ tends to give me the fear anyway these days. (which is fine as it fucks with my concentration for days afterwards. Better off without it.)



Also bump on the hydro plus muscle relaxers. I only had access to flexeril, but man, I felt like Homer Simpson going off into sleepland, where the moon winks at him and the clouds turn into beds. Ahhhhh.


I really need to give tramadol a shot.

cocaethylene













"There are no shortcuts to any place worth going.


One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.




Give Stimulant X from AX a shot, everyonez talkin abt it  ... and its free

XCeed is a CEE with some other boosters - nothing that looks like a stim. to me.

yerba mate wisdom of the ancients vanilla yerba mate and guayaki's

PW could definitely help out. Cordygen5 and Citruvol would be a great combination, also. It would help improve endurance, strength, oxygen utilization, ATP production, recovery, etc. In turn, it could make for an easier work day

Thermolife Stizm. WOW. this is my all time fave



Centrophenoxine 500 mg 60 caps


Pyritinol 400 mg 60 caps


Alpha GPC 300 mg 60 caps


CDP Choline 250 mg 60 capsules


DMAE Bitartrate 150 mg 200 capsules


Acetyl-L-Carnitine 500 mg 100 capsules


Aniracetam 750 mg 60 capsules


Idebenone 180 mg 60 caps


Super Ginkgo Extract 28/7 120 mg 100 caps


























Supplements:


Pramiracetam

Hydergine

Phenibut

Idebenone

Roxindole

Phenylpiracetam Carphedon' or 'Phenotropil So I have tried a bunch of legal and quasi-legal stims, all with disappointing results (ephedrine, caffeine, 1-3-dimethylamylamine, BZP, etc.) But the other day I found a website selling phenylpiracetam. This is more well known as 'Carphedon' or 'Phenotropil' - an obscure Russian stimulant developed to keep astronauts awake on long missions, and occasionally used in Russia as a prescription nootropic for various types of neurological disease. It became well known a couple years ago when a bunch of athletes got kicked out of the Olympics for using it, leading a nootropic supplier in California to start selling it on the Internet as a supplement.

http://www.tradekey.com/index.html?action=buyoffer_manage&track=success&msg=Your%20buy%20offer%20has%20been%20posted%20successfully!%20It%20will%20be%20available%20for%20display%20in%20some%20time&source=buyoffer&keyword=Carphedon,%20Phenotropil,%20Phenylpiracetam%20&sendemail=1

Adapton Iherb.com

"Depressant" and "euphoriant" are distinct is because we have classes of drugs that can fairly selectively achieve either one or the other effect. Confounding the issue, we also have classes of drugs which may produce both euphoria and an antidepressant effect, ie Parnate, Nardil, Amineptine, ketamine, certain cannabanoids, and possably the opiates etc.


INCREDIBLE POST:

POSTED ON: In reply to Re: Vicodin and Percocet for Depression » linkadge, posted by Quintal on August 15, 2007, at 0:32:15 http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20070815/msgs/776511.html


17) Morphine, a mood brigtening smart drug http://opioids.com/cogmood/morphine.html 18) Case studies, long term relief of depression in highly refractory cases with fixed doses of oxycodone. http://opioids.com/antidepressant/opiate.html 19) Use of opiates in highly refractory AD and ECT nonresponse. http://opioids.com/antidepressant/opiates.html 20) The DST and as predictor of response to opiates. http://opioids.com/antidepressant/depression-subtypes.html 21) Methadone and morphine in depression http://opioids.com/antidepressant/index.html 22) The antdepressant effect of endomorphins. http://opioids.com/endomorphins/antidepressant.html

http://www.druglibrary.org/Schaffer/heroin/methadone/toxicity.htm

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=substance+P+inhibitors#hl=en&expIds=17259,17315,18167,20782,23628,23670,23945,25646,25834,25907,26328,26637,26746,26761,26849,27000&sugexp=ldymls&xhr=t&q=substance+P+produce+euphoria&cp=28&pf=p&sclient=psy&safe=off&aq=f&aqi=&aql=&oq=substance+P+produce+euphoria&gs_rfai=&pbx=1&fp=8d771dec467097a5

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=PEPTIDE+TRANSMITTERS:+A+UNIFYING+HYPOTHESIS+FOR+EUPHORIA,+RESPIRATION,+SLEEP,+AND+THE+ACTION+OF+LITHIUM

http://www.dr-bob.org/babble/alter/



Possible new stimulants / euphoriants / and pro-social substances and compounds:

"Substance P"

NK1 receptor antagonist or inhibitor significant increase in dopamine secretion into the nucleus accumbens

These data attest to the reinforcing characteristics of an enkephalin analog

Natural polypeptides may contribute to the reinforcing properties of opiate drugs.

Acute administration of short-acting opiates in animal models causes a reduction in FSH and LH levels, a reduction in glucocorticoid levels, and an increase in prolactin levels. In studies of methadone-maintained patients, several workers have found that plasma levels of FSH and LH may be significantly reduced in some patients during the first year of chronic treatment (Table 7). In both prospective and special studies, it has been shown that levels of these hormones returned to normal after two or more years of chronic methadone treatment. However, we have found that testosterone may remain decreased in around 20-30% of patients after one year of chronic treatment.

It has been well-documented that the acute or subacute administration of narcotics to humans results in a predictable significant reduction in plasma cortisol levels, presumably reflecting a reduction in ACTH levels. It has also been shown that during cycles of subacute or chronic morphine administration in former heroin addicts, both cortisol levels and total urinary excretion of glucocorticoids are reduced. However, our group and others have shown that during chronic long-term methadone administration, plasma cortisol levels are within normal range with a brisk but normal circadian variation.7, 88, 25, 37 In recent studies to be discussed in more detail, we have also shown that plasma levels of ACTH are normal in patients during chronic long-term methadone maintenance treatment.37 In early studies reported in 1972 and 1974, we have found that during the first 2 months of chronic methadone treatment, significant alterations of function of the hypothalamic-pituitary adrenal axis do exist, as evidenced by abnormal metyrapone test results, indicating reduced hypothalamic-pituitary reserve for release of tropic hormones.8, 25 We showed that tolerance develops to this effect after three or more months of stabilized methadone treatment.

































































































ANTI AGING DOCTOR LIST BELOW:

REGIMEN:
PQQ (pyrroloquinoline quinone) 50mg's/day Aniracetam 750 mg each /4X/day Centrophenoxine 500 mg 4/day x 4 days on, 4 days off Acetyl-L-Carnitine 500 mg / 3 - 4 per day (high dose) DMAE Bitartrate 150 mg / 3 per day Alpha GPC 300 mg each / 2 per day Omega-3 EPA/DHA  2x day http://j.mp/yoYGvO http://j.mp/slash-risk-of-premature-death-85-percent 5-MTHF 50mg / 1X day Pyritinol 400 mg each / 1 per day CDP Choline 250 mg / 2 per day Idebenone 180mg  / 1 - 2 per day Life Extension Super Ginkgo 120mg / 2 day Ubiquinol Benfotiamine Rhodiola
Phosphatidylserine  http://j.mp/zGl4hK S-adenosylmethionine http://j.mp/Aisb71


Interesting pharma or RC ("research chemical"):

Prolintane aka Catovit

1-(thien-2-yl)isopropylamine

Butylone


Interesting Nootropic: Rolipram (http://j.mp/rolipram)

CX717
“It generates a state of cortical wakefulness without stimulation,” says Gary Lynch at the University of California at Irvine, who invented ampakines. Cortex Pharmaceuticals Inc., based in Irvine, California

Ampakines work by binding to particular receptors in the brain, called AMPA-type glutamate receptors. This boosts the activity of glutamate, a neurotransmitter, and makes it easier to encode memory and to learn. And because of their short half-life - hours in this case - ampakines have few side effects.

Rasagiline & Selegiline By inhibiting MAO-B, rasagiline prevents the deamination of the monoamines dopamine and phenethylamine (PEA), thereby increasing their concentration in the synapse and curbing production of the reactive oxygen species, hydrogen peroxide. High concentrations of hydrogen peroxide are associated with increased oxidative stress. Rasagiline both raises levels of striatal dopamine produced from levodopa and improves the survival prospects of ailing dopaminergic neurons themselves. This salvage job helps restore a measure of normal locomotion, gait and coordination in Parkinsonian patients while delaying their physical decline.

Both selegiline and rasagiline are neuroprotective via multiple mechanisms that are poorly understood. However, their role in stabilising mitochondrial membrane potential is critical. The propargylamine moiety rather than MAO inhibition per se apparently holds the key to their neuroprotective action: the S isomer of rasagiline is some 1000 times less potent as an MAO inhibitor, but it's still protective against neurotoxic insults. Rasagiline inhibits activation of the apoptotic cascade triggered by dopamine neurotoxins and oxidative stress. Apoptosis is an active process of programmed cell-death induced by exposure to neurotoxins. Rasagiline and other propargylamines can rescue deteriorating dopaminergic neurons by inhibiting the "death signal" transduction-mechanism of mitochondrial permeability transition. Current evidence suggests that rasagiline may be more effective than selegiline in salvaging dopamine nerve cells from the usual neurological carnage of later life.


Two fascinating Russian chems and experience reports:

Cerebrolysin It's the second day I take cerebrolysin only. The effect is very interesting, I wake up very energetic, my sensitivity to caffeine has increased a lot. A cup of espresso is too much for me.

Cerebrolysin appears to have some kind of antidepressant / anti-anxiety effect. I have never used anxiolytics or antidepressants before but I noticed that I don't feel depressed or anxious under extremely stressful situations. I had trouble getting asleep as well, but now I just go to my bed and I get asleep in 10-15 mins.

Cerebrolysin probably does not have a typical antidepressant / anxiolytic affect. I guess that you can only notice the effect of cerebrolysin if you have to undergo extremely high workload, stressful situations... I simply don't get tired and I can relax much easier after any stressful event

This nootropic is one of those which have a very pronounced effect and it scares me  To be honest, it is one of the reasons I will not continue taking cerebrolysin. Nobody knows what are the long term effects of this drug. I am a healthy individual, so I don't see any need to take a risk and use it any longer. However it was a positive experience


Phenotropil works wonders when I take it with Semax.

The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"

It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.

Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.

As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.

I hope this is useful to everyone interested in this peptide.


Fascinating Nootropic and notes + list:

Noopept.

1010pharma.com is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax right now, anti-aging.com may carry...

One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

http://www.apteka-dr...erc-3ml-n1.aspx

phenylpiracetam

http://www.backtone.com/

N-PEP-12(MemoProve) which is a derivative of Cerebrolysin

Memantine - Namenda

Alpha GPC

Selegiline - Deprenyl

Horny goat weed - Same as above. PDE5 inhibition could be helpful as well on occasion (those first couple hours of amphetamine are brutal).

Agmatine - It's an obscure possible neurotransmitter produced from arginine that among many possible benefits blocks NMDA receptors and thus hopefully helps mitigate amphetamine tolerance. It may improve mood, memory, and sleep as well.

Phenibut, while I loved the initial effects, became detrimental VERY FAST (depressant action). So 2-3 times a week seems too much to me. Just be aware of this.

Famotidine - It's an OTC histamine antagonist used as an antacid. I take 20mg once or twice a month because it improves amphetamine absorbtion.

Huperzine A - Again, NMDA action for amphetamine tolerance. Hopefully some memory improvement. I've read that this may be dangerous to take regularly so I will probably go with 200mcg every other day.


Green tea extract - It's high in ECGC. I figured I could use a good anti-oxidant. I will likely take this daily.

Arginine alpha-ketoglutarate - I'm hoping this will help with amphetamine-induced vasoconstriction. Since I'm not a body builder I will probably take a half dose daily for a week and see what happens.



Bacopa - I took it regularly for about three weeks, one dose in the evening. It may of made me drowsy.


Magnesium Glycinate

L-Theanine

Sulbutiamine 300mg

-Sulbutiamine is a funny substance. It's amazing at first. Many have noticed it decreases creativity to an extent, which I would tend to agree with. But it should also be used very sparingly-- tolerance will develop.

Tip: because of the receptors it antagonizes/agonizes, its effects are much more pronounced with caffeine. I.e., it is synergistic. -If you're taking any of these drugs for depression, be very careful with Huperzine A. As an acetylcholineesterase inhibitor, it's a great way to throw off your acetylcholine/dopamine balance (see my post in the research forum).

DL-Phenylalanine Yohimbe
L-Tyrosine Copper Gluconate Choline Bitartrate Dicalcium Phosphate) 120 MG Dicalcium Phosphate) 92 MG L-Potassium Aspartate) 30 MG Propionyl-L-Carnitine 1000 MG L-Asparagine 650 MG Acetyl-L-Carnitine 500 MG L-Potassium Aspartate 150 MG Caffeine (USP) 125 MG L-Tyrosine: 1800mg Acetyl L-Carnitine: 500mg Sulbutiamine: 300mg Rhodiola Rosea: 200mg -(standardized to 3%) Caffeine Anhydrous: 160mg Vinpocetine: 20mg Pyrodoxine HCL: 8mg



Camellia Sinensis 60% Polyphenols (green leaves), Yohimbine Alkaloids (pausinystalia yohimbe bark), 6’ 7’-Dihydroxybergamottin (fruit), Camellia Sinensis 60% Polyphenols (white leaves), Capsaicin (fruit)


Stimulant X www.stimulantx.com

Most frequently prescribed MAOIs include Nardil, Parnate, and Elderpril.

Nicotinic analogues

Gotu Kola,

Damiana

Polar Bear Snuff:

Take CEE and some adaptogens

I like AMP or Focus XT for a neural boost

gatorade

Panax ginseng

palatinose + extra citrulline malate + extra beta alanine + ALCAR + Tyrosine is what Im going with.

Maca

ergopharm's amp...stimx, pumpjuice2.0 (not just a stim).

Glucuronolactone, tyrosine, taurine.

XCeed is a CEE

yerba mate

PW could definitely help out. Cordygen5 and Citruvol would be a great combination, also. It would help improve endurance, strength, oxygen utilization, ATP production, recovery, etc. Could make for an better day at office

Thermolife Stizm. WOW excellent reviews


Metformin
The mechanisms for lifespan extension by metformin are not completely understood yet but probably involve AMPK and its downstream target mTOR (fig. 1) (4). mTOR is also the target of the famous life extension drug rapamycin that increases lifespan in mice both when administered early and during middle life (15,16). mTOR inhibits autophagy thus metformin activates autophagy by inhibiting mTOR. Autophagy clears cells from dysfunctional organelles – such as mitochondria – and other junk that can impair normal cellular functions and thereby extends lifespan. mTOR stimulates protein synthesis and for still very incomplete understood reasons protein synthesis reduces lifespan. Therefore again metformin is expected to retard aging. If the cell cycle is arrested – that is the cell temporally stops dividing – and the cell continues to receive growth signals (mTOR stays active), it can lead to cell senescence – a state of permanent cell cycle arrest (4). Senescent cells secrete proinflammatory molecules, this has been termed the senescence-associated secretory phenotype, and can locally stimulate tumor growth (17). Metformin is expected to prevent cell senescence by removing the growth signal pressure. AMPK inhibits NAD(P)H oxidase, an enzyme whose action produces superoxide – a free radical. Metformin thus decreases free radical production (4). Free radicals are molecules that have an unpaired electron, they desperately try to find an extra electron to stabilize their configuration and in the process destroy other molecules by stealing their electrons. The free radical theory of aging is without doubt the most well known mechanistic aging theory. It was first proposed by Denham Harman in 1956 (18). Since then the failure of antioxidants to extend the lifespan has cast doubt on the validity of the free radical theory but still most biogerontologists think that free radicals do play a certain role. In fact some even suggest that the failure of antioxidants is expected because they undermine the bodies stress response (19). AMPK can be activated by: (i) binding of AMP, and (ii) phosphorylation by other enzymes. Metformin has clearly been shown to increase the phosphorylation of AMPK but the effects on AMP are disputed. Phenformin and buformin inhibits complex I of the respiratory chain, so maybe metformin does so too. Such an inhibition would decrease ATP – the universal energy currency for life – production and thereby increase AMP levels.

Phenylpiracetam, Phenotropil, Fenotropil, Carphedon

Fenotropil has a positive effect on metabolism and blood circulation within the brain. It stimulates the Redox processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in Ischemic areas of the brain. Moreover, it increases noradrenaline, dopamine, and serotonin brain levels. It does not affect GABA levels and is not associated with GABA A- and -B receptors. It produces no significant effect on spontaneous brain activity.

Fenotropil has no effect on the respiratory and cardiovascular systems. However, it produces a mild diuretic effect and anorexic activity in the exchange application.

Fenotropil provides a moderately stimulating effect on motor responses and improves physical performance. The moderate awareness-inducing effect of the drug is combined with anxiolytic activity. Fenotropil improves mood and has analgesic effects, increasing the pain threshold. Additionally, it has an adaptogenic effect, increasing the organism's resistance to stress in conditions of increased mental and physical stress and fatigue. Furthermore, it increases resistance to freezing hypokinesia.

With the advent of Phenotropil, marked improvements were noted in vision (an increase in sharpness, brightness, and field of view). Fenotropil improves blood flow to the lower extremities. Fenotropil stimulates the production of antibodies in response to the antigen, indicating that it has immunostimulator properties but at the same time does not cause the development of immediate hypersensitivity reactions and does not alter the allergic inflammatory reaction of the skin caused by the introduction of foreign proteins. In the exchange application, Phenotropil does not develop drug dependence and tolerance. The drug is not marked in the development of withdrawal syndrome.

Actions of Fenotropil are seen after a single application, which is important when the drug is used in extreme conditions. Phenotropil significantly enhances the action of other Nootropic drugs.

Fenotropil is not metabolized in the body and excreted, unchanged in form. About 40% is excreted in the urine and 60% in bile and sweat. The half-life is 3-5 hours. The average single dose is 150 mg (100-250 mg); the average daily dose is 250 mg (200-300 mg). The maximum daily dose is 750 mg. The multiplicity of reception is 1-2 times a day. A daily dose of 100 mg can be taken one time a day (morning), while doses exceeding 100 mg should be taken in two doses. The duration of treatment ranges from two weeks to three months. The average course of treatment is 30 days.















BORDERLINE ANALOGUES?

Dimoxamine

DOM

2C-I

2C-I and 2-CT-2

2C-I (2,5-dimethoxy-4-iodophenethylamine) Most likely candidate for the coveted title "the next ecstasy".



http://medi.ru/doc/3101.htm http://www.phenotropil.ru/pub/


http://www.google.co...JwsQRjQ&cad=rja

I see that there's a way to order this out of Russia (www.1010pharmacy.com) or the UK (www.antiaging-systems.com). There's probably a few others too...

http://www.drugs-pro...lysin-10ml.html

kunwha.com




Cerebrolysin has to be injected intravenously or intramuscularly. It cannot be injected into the fatty tissue. An intramuscular (IM) injection is a shot where the needle goes into the muscle layer under the skin to deliver medicine. IM injections are deeper than subcutaneous injections (given under the skin). Parts of the Body Involved - Upper arm, Top of the thigh, Buttocks (most common and recommended for 5 ml cerebrolysin injections).

A needle passes through skin and fat layers into the muscle fibers to deliver medicine.



I am not advising anyone to do this if you have never done it before. You should consult your doctor or ask someone who is experienced to do the injection for you.

http://www.longecity.org/forum/topic/28171-cerebrolysin/




I have a few questions if you wouldn't mind answering them?

1) How long did you use it for? I beleive there's five 5 ml ampoules in each packet. It sounds like you took 5 ml (first day), 5 ml (2nd day), 10 ml (3rd day), then possibly 5 ml the 5th day if you used all the ampoules up?

2) Dosaging Instructions According to Antiaging-Systems: The normal dosage pattern seems to be to do an injection 5 days out of a 7 day week for 4 weeks. Alzheimers patients (or possibly certain people suffering a delay of some sort to a lesser severity) would take 1 ml, 5 ml, or 10 ml ampoules once a day Mon.-Fri. (or whatever's 5 days; skipping 2 days each week) for 4 weeks (before waiting 3 months to begin again). The benefits are supposed to last possibly up to 3-6 months.

With that being said, 10 ml seems like it could potentially be a bit much for a healthy person to take. Did you notice a direct difference between the 5 ml on the 1st day vs. the last day? Or the 5 ml (from the 1st and last day) vs. the 10 ml?

3) Any dizziness, headache, or heat sensations? According to http://www.antiaging...erebrolysin.htm these are some rarer side-effects that may occur if administered too quickly? (meaning possibly jumping right up to 10 ml could of been done too quickly?)

4) It doesn't appear side-effects are common. Perhaps a healthy person could order 10 1 ml ampoules (this is much cheaper for around $50) instead of the 5 5ml (around $70) or 5 10ml (around $90). This would mean for $100 someone could do the 4 week program using only 1 ml ampoules instead of paying around $280 for a 4 week program using 5 ml ampoules.

5) I don't want to throw this thread off track here but have you heard of "Cortexinum"?http://www.pharmacy1...age.asp?id=1375 It seems surprisingly similar to Cerebrolysin. I'm wondering if this is some sort of Russian variant brand of Cerebrolysin?



I will post this again:

There are no Cerebrolysin alternatives which can be taken orally except N-PEP-12(MemoProve) which is a derivative of Cerebrolysin and it is much less potent.

Effects of N-PEP-12 on memory among older adults.

Crook TH, Ferris SH, Alvarez XA, Laredo M, Moessler H.

Psychologix, Inc., Fort Lauderdale, FL 33308, USA. tcrook@psychologix.com



1) I had 2 packs of cerebrolysin. I used 5 ml for the first 3 days and 10 for ml for 2 days.

2) I did not notice anything for the first 2 days. The effect became really noticeable on the 3rd day, even more noticeable on 4th and 5th. Btw, 1 ml ampules are usually given to kids.

3) I did not feel any dizziness, headache, or heat sensations. Those side effects usually occur when you inject a cold liquid intravenously. To avoid this it has to be warm enough (room temperature) and you have to inject it slowly.

4) 1 ml is a very small dose, it is not enough even for a healthy adult. I have read the instructions and it says that doses of 1-2 ml are given to kids. Doses up to 50 ml (IV) can be given in severe cases. Cerebrolysin is overpriced if you buy it online. I bought another pack of cerebrolysin while traveling in one of the EU countries, the price at the pharmacy was 34 USD (5 x 5ml amp)

5) If I remember correctly cortexin is made from cattle brain. I will try to get some more info about it. Edited by anony4mous, 22 April 2009 - 01:32 AM.



Cortexin peptide drug is largely similar to the cerebrolysin, used also by intramuscular injection./Pharmacological Effects: The drug improves cerebral metabolism. Cortexin represents liofilizat obtained by acetate extract from the bark of the brain of cattle or pigs, which contains low-molecular active neuropeptides, the molecular weight of not more than 10 000 dalton, sufficient to penetrate through hematoencephalic barrier./Cortexin has a unique multi-effects on the brain, as demonstrated in metabolic regulation, neuropatronage, functional neuromodulation, neurotrophic activity. Cortexin improves the efficiency of energy metabolism of brain cells, improves the intracellular synthesis of protein, regulates the processes of oxidation of lipids in cells of the brain reduces the formation of free radicals, blocking the processes of free-radical oxidation. The product eliminates the imbalance of braking and excitatory amino acids, has a moderate GABA-ergic action./The drug has a positive effect in violation of cognitive function, improves concentration, short-term memory, learning ability, accelerates the recovery of the functions of the brain after stress effects, regulates the levels of serotonin and dopamine. It stimulates the process of mental activity, not providing excessive activation of influence, restores bioelectric activity of the brain, stimulates the reparative processes in the brain./Indications for use: Violations of the cerebral circulation; encephalopathy of different genesis, acute and chronic encephalitis and encephalomyelitis, epilepsy, brain trauma, viral and bacterial neuroinfection; infantile cerebral palsy, delayed psychomotor and speech development in children; asthenia, memory, thinking, reducing the ability to learn.


Concentrate always means - impure. Hydrolyate means a more exact synthesis of adding hydrogen to the the purified mix. Both kinda suck, because all you want is the chemical, but what the process gives you, is impurities. The more you get rid of that - the higher the costs get.



I was taking up to 10 ml of cerebrolysine daily at work though I/M injections, easily for a good 6 months if not more. (Usually in 2 injections, although I've shot 10ml straight up before in one large syringe) Since I worked in 4-day shifts, I'd usually go 4 days on and then 4 days off to cool off my neurons  That easily allowed me to handle all the stresses, and I was one of the best at that particular job. Despite having abused illegal drugs in the past and being a frequent cannabis smoker, I experienced little to no "stoner burnout" and was able to concentrate and perform tasks faster than most of my colleagues at the same experience level. After a long 12-hour work day, after which a normal brain turns to mush, I was still fresh and eager to go out with friends/ see girls etc, while otherwise I'd be drained and only wanting to sleep.



So instead of rambling on further, let me just break down some effects and side-effects, short and long term:

-This stuff has a MARKED anti-depressant effect. You basically feel like back in the happiest moments of your childhood. Everyone has had one of those days when they're just "on fire" and "on top of the game". With Cerebrolysine, pretty much every day is like that - you're not overly happy or vegetated like off standard anti-depressants, but you're "on point" at whatever you do. Stuff like your subconscious and conscious fears all go right out of the window, and it has a bit of a socially-inhibiting effect too.

-If you thought weed gets you the munchies, wait till you try this stuff. When you first start on this cycle, you get hungry as a SAVAGE. I usually eat just enough to be full, not overly gorged, but this stuff had me tearing up huge meals and not even feeling incapacitated by everything I just ate. I'd attribute this to the fact that with all the additional peptides and stuff, your body needs more nutrition. Sort of like adding B-vitamins to stuff like Pyritinol or even good old 5-HTP.

-Cerebrolysine helps alleviate most, if not all symptoms of post-intoxication syndrome for illicit drugs. I once gave my friend a shot after his most recent cocaine binge and he turned from a pale shadow who was about to pass out back to his normal self - energetic, enthusiastic, and motivated. Plus his foul mood and edginess were completely gone. It also seems to ease the alcohol-related hangover better than some other substances (although many nootropics are much better for that IMO since they're GABA-active). My other friend also liked taking it as a "corrector agent" for other nootropics/supplements, claiming it helped alleviate certain unwanted effects of piracetam, while preventing one from overloading on one particular amino acid too much. I personally avoid ALL other substances when doing cerebrolysine. It simply overshadows them all for me.

-They definitely put some kind of a painkiller in there. Shooting cortexin (which is similar, but I like it alot less, as it "vegetates" and sedates me too much to where I'm more mentally capable, but simply don't care) without a novacaine solution is literally a huge pain in the rear, while shooting straight cerebrolysine into my tiny tricep with a huge needle made my whole arm go numb for a short time, like an anastetic would.

-I've measured my blood pressure several times before and after the injections, and there is a slight blood pressure elevation. If you inject too fast, the heart rate jumps and you may sweat profusely. However it gives you a nice sort of a "rush" to where you feel very relaxed, but not incapacitated or drugged by any stretch of imagination. The headaches are there, but are very slight, and usually start about 2-3 hours after the injection.

-The long-term effects aren't so pleasant. There is an increasing feeling of "mounting personal hell" as I like to call it. Basically, all the negative traits of one's character seem to be unnaturally emphasized and underlined in your mind, while the positives seem little and insignificant. It doesn't really manifest itself in a severe form to others, but you may feel "grumpy" and "dissatisfied" even when you seem to be razor-sharp mentally. A good comparision would be some rich spoiled kid who has everything throwing tantrums and breaking stuff, just because he is rich and spoiled. Several of my friends reported very similar mental side effects. This is what initially led me to stop taking it by "tapering down" (I don't think it's a good method by the way, but since I was doin it daily for a while I decided for a slower descent). A .5 ml less every day for several days, then a week at 1ml and then 0.5 and then you're shooting colored water for placebo effects

- Some people report a HUGE boost in their sexual activity. I noticed only a slight boost

- When you're off the cerebrolysine, you feel like it's a bad day for no reason (see above having a top of your game day for no reason lol). I didn't notice any significant negative long-term effects on my cognitive processes. On the contrary I seem to be able to concentrate better at any time, without taking any substances, or even after smoking a lot of weed. I'm now able to "zone in" on something more completely and do better at focusing.

-This stuff has very strong and powerful overall effects, it is the most effective out of injectable nootropics/smart drugs that I've tried. Cortexin doesn't even come close, and various Cerebrolysine derivatives (we ahve a Cerebrolysate here) are nothin more than cheap imitations.

I've decided for another mini-cycle just now, about 3 years after that last lengthy episode. I'm sticking to what the doctors here recommend: 5ml every OTHER day. Seems to be the correct dosage and schedule.

I hope it doesn't sound too much like promo for the Austrian pharmaceuticals company which makes this stuff. It's really not somethin you want to mess around with if you don't know what you're doing.



http://www.longecity.org/forum/topic/28171-cerebrolysin/page__st__30




THE FOUR CRIMINALS BEHIND AGING: 1. Methylation 2. Oxidation 3. Glycation 4. Inflammation


Glycation, Methylation, Inflammation,


This is a chemical process that takes places in the body, which binds sugar and proteins. This binding with sugar makes the structural proteins in your body stiffer and contributes to accelerated aging by reducing flexibility of tissues and organs.

The formation and accumulation of advanced glycation endproducts (AGEs) has been implicated in the progression of age-related diseases.[8] AGEs have been implicated in Alzheimer's Disease,[9] cardiovascular disease,[10] and stroke.[11] The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis.[12] They form photosensitizers in the crystalline lens,[13] which has implications for cataract development.[14] Reduced muscle function is also associated with AGEs.[15]

It is not yet clear whether glycation can actually be reversed, however research is currently being conducted on a class of chemicals called AGE breakers. These drugs would theoretically “undo” the damage in glycated tissues, returning them to their normal state.




For all the promise of youth-restoring remedies none has ever reversed the process of aging. Now, for the first time, researchers at Alteon Inc. (alteonpharma.com) have developed a drug that rejuvenates hearts and blood vessels, stiffened with age, by breaking up molecules that cause the trouble.





Anti AGEs

elusive alt-711 (alagebrium)

Aminoguanidine


NtBHA (Geronova) N-acetyl-L-carnosine (NALC) (Superior Nutracuticals)






MDD

Quercetin

Fisetin
Similar to many other flavonoids such as the structurally related flavonol quercetin, fisetin is a potent antioxidant. Its antioxidative activity may be due to its structural properties[11] as well as to its ability to modulate certain cellular signalling pathways, especiallyprotein kinase and lipid kinase pathways. For example, fisetin has been shown to induce the transcription factor Nrf2,[12] leading to increased expression of several protective and antioxidative genes. One study at the Salk Institute found that fisetin may help improve memory and protect the brain from the onset of Alzheimer's disease and also that it may be useful for reducing kidney failure in diabetics.[4] [edit]
Side effects Fisetin was, among other flavonoids, found to be a strong topoisomerase inhibitor.[13] This effect may be responsible for both anticarcinogenic and carcinogenic potentials of the substance.[14] Fisetin among otherflavonoids is suspected to increase risk of infant leukemia (which is rare disease).[15]

Rapamycin
Rapamycin was first shown to extend lifespan in eukaryotes in 2006.[17] Powers et al. showed a dose-responsive effect of rapamycin on lifespan extension in yeast cells. Building on this and other work, in a 2009 study, the lifespans of mice fed rapamycin were increased between 28 and 38% from the beginning of treatment, or 9 to 14% in total increased maximum lifespan. Of particular note, the treatment began in mice aged 20 months, the equivalent of 60 human years. This suggests the possibility of an effective antiaging treatment for humans at an already-advanced age, as opposed to requiring a lifelong regimen beginning in youth.[18] Because it strongly suppresses the immune system, though, people taking rapamycin are more susceptible to dangerous infections. It is not known whether rapamycin will have similar lifespan-lengthening effects in humans, and study authors caution the drug should not be used by the general population for this use.







Omega-3 EPA/DHA  http://j.mp/yoYGvO

































MDD SELF:

Furazabol  cutting, vascularity, weight, cholesterol improvement:  However, recently 100 mg/mL versions have become available. A common dosage can be 10–25 mg/day orally and 25–50 mg daily injected, with optimal results usually seen at 50 mg/day.

best: Cimaterol fat burner


L tartrate


Cytomel: Thus we can see that there are many advantages to using Cytomel to optimize our metabolic rate. It will also increase your bodys ability to synthesize protein, but from what Ive seen personally, it acts as a catabolic when it isnt administered with anabolic steroids. It is often the last thing added into a precontest diet, as it has a reputation for getting rid of the last few percentages of bodyfat& the "sticky fat" as its called in bodybuilding, the fat that just doesnt want to leave you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a diet to lose fat, as it will optimize your metabolic rate, which should be done at the outset of a diet, not after the calorie restriction has diminished your thyroid output and you are adding it in simply to replace what was lost.

Read more: http://www.steroid.com/Cytomel.php#ixzz1iwD2YLl4




Most users experience a very strong energy rush within 15 minutes of each dose. This characteristic makes it a popular pre-workout intensity pill. Approximately 8% of users experience the opposite effect making them drowsy. For this group of individuals, taking Clen at night before bedtime is a reasonable compromise.

Read more: http://www.steroid.com/Clen.php#ixzz1iwDWOj6W

ounterfeits have been reported but not confirmed to date. Clen is easy to find and inexpensive making it less desirable to fake. You can get real Clen at Anabolic Research. Each bottle of Clen has a holographic logo applied to the label to ensure its authenticity.


Read more: http://www.steroid.com/Clen.php#ixzz1iwDjbIoy




Highly Effective (Clen + T3) 6 Week Weight Loss Cycle Available With Dianabol Shop





Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats. http://www.ncbi.nlm.nih.gov/pubmed/22135908


Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. Finally, increasing CREB expression after withdrawal from self-administration enhanced cocaine-primed relapse, while reducing CREB levels facilitated extinction of cocaine seeking, but neither altered relapse induced by cocaine cues or footshock stress.






What I've read about Memantine on a large number of internet sites tells me it is believed to work by protecting nerve cells from being killed off by glutamate toxicity. This happens in Alzheimer's when a certain type of receptor on the cells, the NMDA receptor, is over-stimulated by glutamate and releases an overload of calcium into the cell, killing it. Memantine regulates the calcium flow by partially blocking the NMDA receptor. Although memantine is the patented, prescription drug which does this, so it is claimed do a number of non-prescription dietary supplements. For example, Huperzine A, apart from its main function as a cholinesterase inhibitor (like Aricept, Exelon, etc) also protects against glutamate toxicity; so does Theanine, a natural relaxant derived from green tea, and the safe non-prescription form of lithium (lithium orotate) also, (lithium has also been shown to inhibit the AD protein tangles, and, surprisingly, to increase the volume of grey matter in those taking it for manic depression).




she needs the Huperzine three times a day, (total dose 350 mcg) as it's possible to detect when a dose is wearing off.


She also takes mutivitamin/mineral mixes (crushed onto her breakfast cereal) with extra vitamin E and the methylcobalamin form of B12. In addition, because of its reported action similar to that of memantine (my last posting) I also give her Theanine, which also has a relaxant/mood-elevating effect without drowsiness. The Lithium info I found recently, and it is being considered for Alzheimer's trials. As it's available in safe supplement form as lithium orotate, I give her that also, (one capsule daily) and it does seem to be giving her an extra improvement in mood, and she has a good sense of humour, often with fits of giggles! I read about the effects of Lithium orotate at a number of sites. It should be stressed that this only applies to the orotate form of lithium, which is non-prescription and doesn't need regular blood monitoring like the stronger prescription forms do. Apart from its effect on stabilising mood, which often becomes very erratic in AD, research shows it has a very strong nerve protective action, and also inhibits formation of the Tau protein (part of the toxic build-up in AD). So should be good all-round AD treatment. My mother certainly seems better mood-wise with it (and the other supplements) but its impossible to know what's actually happening to her brain cells, and how long any results might take to show.


Have you ever considered adding OPCs? They are a super powered antioxidant that oxygenate the blood. This gets more oxygen to all parts of the body, especially the brain. You can look up OPCs on websites or email me for more info.


Galantamine used with choline bitartrate or Alpha-GPC Galantamine has been used as a sleep aid, Galantamine has been anecdotally described both to help people fall asleep and increasing the quality of sleep once someone falls asleep. Extensive research and sleep studies have not been conducted, but initial microbiological research suggests that Galantamine does have properties that can aid patients suffering from insomnia.

D1 dysphoric D2 euphoric


Guys you might like this one 7-amino-8-hydroxbutyric acid (GABOB) Google it. Nutraplanet might be getting it. For it to have ghb effects it has to be injected.No thanks are there any benifits taking orally? Not that I see ! I wish ghb could be illegal by us responsible folks.

chocamine+deprenyl+inositol+bacopa+sam-E I take 1 gram of theanine, 1 gram of Green Tea, Fish Oil, and two amp.


Hydrocodone (or codeine) + Carisoprodol.

Piractem, Sulbutamaine, choline

Cytolean by Gaspari is pretty smooth



Sci-Vi Dianle 4



Stim X is too much



Tryosine is always nice



Smart drugs-Piractem, Sulbutamaine, choline





Methylphenidate (I.V, snorted or oral, your choise)

+ Ma-huang (oral) and or Sida cordifolia (oral) / Or ephedrine HCL

+ Nicotine (snorted, smoked, oral, or dermal)

+ Caffeine (snorted or oral)



Optional ad on

+ Tyrosine (oral)

+ ALCAR (oral)

+ (K)-R-ALA (oral)

+ some cayenne/chili/natrium bicarbonate for absortion



This combination in the right dosages gives a warm and pleasant feeling, tremendous euphoria (like MDMA) and a lot more self esthem (like coke)





Yeah, xanax + tramadol is some good times. First time I mixed tramadol with some KB it made things a bit too much. Like verging on bad trip too much. But I had about 400mg tramadol in my system and MJ tends to give me the fear anyway these days. (which is fine as it fucks with my concentration for days afterwards. Better off without it.)



Also bump on the hydro plus muscle relaxers. I only had access to flexeril, but man, I felt like Homer Simpson going off into sleepland, where the moon winks at him and the clouds turn into beds. Ahhhhh.


I really need to give tramadol a shot.

cocaethylene













"There are no shortcuts to any place worth going.


One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Many researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pleasure itself. Dopamine amplifies "incentive-motivation": "wanting" and "liking" have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.




Give Stimulant X from AX a shot, everyonez talkin abt it  ... and its free

XCeed is a CEE with some other boosters - nothing that looks like a stim. to me.

yerba mate wisdom of the ancients vanilla yerba mate and guayaki's

PW could definitely help out. Cordygen5 and Citruvol would be a great combination, also. It would help improve endurance, strength, oxygen utilization, ATP production, recovery, etc. In turn, it could make for an easier work day

Thermolife Stizm. WOW. this is my all time fave



Centrophenoxine 500 mg 60 caps


Pyritinol 400 mg 60 caps


Alpha GPC 300 mg 60 caps


CDP Choline 250 mg 60 capsules


DMAE Bitartrate 150 mg 200 capsules


Acetyl-L-Carnitine 500 mg 100 capsules


Aniracetam 750 mg 60 capsules


Idebenone 180 mg 60 caps


Super Ginkgo Extract 28/7 120 mg 100 caps


























Supplements:


Pramiracetam

Hydergine

Phenibut

Idebenone

Roxindole

Phenylpiracetam Carphedon' or 'Phenotropil So I have tried a bunch of legal and quasi-legal stims, all with disappointing results (ephedrine, caffeine, 1-3-dimethylamylamine, BZP, etc.) But the other day I found a website selling phenylpiracetam. This is more well known as 'Carphedon' or 'Phenotropil' - an obscure Russian stimulant developed to keep astronauts awake on long missions, and occasionally used in Russia as a prescription nootropic for various types of neurological disease. It became well known a couple years ago when a bunch of athletes got kicked out of the Olympics for using it, leading a nootropic supplier in California to start selling it on the Internet as a supplement.

http://www.tradekey.com/index.html?action=buyoffer_manage&track=success&msg=Your%20buy%20offer%20has%20been%20posted%20successfully!%20It%20will%20be%20available%20for%20display%20in%20some%20time&source=buyoffer&keyword=Carphedon,%20Phenotropil,%20Phenylpiracetam%20&sendemail=1

Adapton Iherb.com

"Depressant" and "euphoriant" are distinct is because we have classes of drugs that can fairly selectively achieve either one or the other effect. Confounding the issue, we also have classes of drugs which may produce both euphoria and an antidepressant effect, ie Parnate, Nardil, Amineptine, ketamine, certain cannabanoids, and possably the opiates etc.


INCREDIBLE POST:

POSTED ON: In reply to Re: Vicodin and Percocet for Depressio » linkadge, posted by Quintal on August 15, 2007, at 0:32:15

Fascinating forum discussion on the potential utility of opioids to combat treatment resistant depression:

http://j.mp/opiatesfordepression



Another:

Morphine, a mood brigtening smart drug?  http://j.mp/opioidsfordepression

Case studies showing long term relief of highly refractory depression cases with use of oxycodone: http://j.mp/oxycodonefordepression

http://j.mp/depressionandopiates

http://opioids.com/antidepressant/depression-subtypes.html

Methadone and morphine in depression: http://opioids.com/antidepressant/index.html 

22) The antdepressant effect of endomorphins: http://opioids.com/endomorphins/antidepressant.html

http://j.mp/substancePinhibitors

http://www.google.com/search?sourceid=chrome&ie=UTF-8&q=PEPTIDE+TRANSMITTERS:+A+UNIFYING+HYPOTHESIS+FOR+EUPHORIA,+RESPIRATION,+SLEEP,+AND+THE+ACTION+OF+LITHIUM

http://www.dr-bob.org/babble/alter/

"Substance P"

NK1 receptor antagonist or inhibitor significant increase in dopamine secretion into the nucleus accumbens.



































































Christian Hunter's Twitter Latest