tag:blogger.com,1999:blog-28731777514441593.post4602449578948191620..comments2023-08-16T03:53:02.931-07:00Comments on Christian Hunter: The Best New Senolytic Isn't a Drug...or New For That Matter.Christian Hunterhttp://www.blogger.com/profile/09785910208611025614noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-28731777514441593.post-31213287239118724722021-06-09T04:07:37.108-07:002021-06-09T04:07:37.108-07:00I have had chronic fatigue since 2003. I never fe...I have had chronic fatigue since 2003. I never feel like I got rest from sleeping and my legs feel so heavy. I have tried so many things like many peptides some seamed to help a tiny bit but never a cure. I weigh 265 lbs. 2 days ago I took 500mg Fisetin to test it out and within an hour or so I noticed I didn't have this twitch on the bottom of my left foot which has been mild but it never stops 24/7 and has been going on for many years. So then I figured it does stop inflammation. The next day I took 2000mg and within a few hours I noticed my legs don't feel heavy. They always feel so heavy and it gets worse if I sit for a while like for lunch and when I go to get up I'm so weak until I move around... Yesterday I didn't have that tired feeling in my legs. Am I 100%, no not yet but this has been life changing for me already as I haven't feel that good for so long. Today I wake up tired but legs aren't as tired as before. I am actually searching the web for reviews so see if people get unwanted side effects as I hate to feel speedy but so far this isn't anything like that. I just felt more normal. I feel like if this continues I will be able to begin to workout again and get my life back within a couple of weeks. Anonymoushttps://www.blogger.com/profile/02836125004528847735noreply@blogger.comtag:blogger.com,1999:blog-28731777514441593.post-61000532064409086602020-10-08T11:48:39.394-07:002020-10-08T11:48:39.394-07:00It’s both available and cheap at amazon
https://a...It’s both available and cheap at amazon<br /><br />https://amzn.to/2I3CvFWChristian Hunterhttps://www.blogger.com/profile/09785910208611025614noreply@blogger.comtag:blogger.com,1999:blog-28731777514441593.post-61134568273542466632020-10-08T10:39:00.709-07:002020-10-08T10:39:00.709-07:00Is it available to public if so where and how much...Is it available to public if so where and how much with instructionsAnonymoushttps://www.blogger.com/profile/04204036933205161704noreply@blogger.comtag:blogger.com,1999:blog-28731777514441593.post-80318134974239984822019-07-15T23:38:42.913-07:002019-07-15T23:38:42.913-07:00https://www.christianhunter.com/2019/05/best-new-s...https://www.christianhunter.com/2019/05/best-new-senolytic.html<br /><br />Hi, Christian. You may by now have heard of the clinical trials of fisetin presently underway at the Mayo Clinic.<br /><br />https://clinicaltrials.gov/ct2/show/NCT03675724?term=fisetin&rank=1<br /><br />https://clinicaltrials.gov/ct2/show/NCT03430037?term=fisetin&rank=2<br /><br />Interestingly, these trials are using a significantly higher dose (20mg/kg) than would be implied by simply adjusting the mouse study below<br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/<br /><br />to a Human Equivalent Dose. And they only employ that higher dose for two consecutive days, not for five consecutive days, as in the mouse study.<br /><br />The mice in that study were fed 100mg/kg of fisetin daily for five days. Dividing by the usual 13.2 factor to get the human equivalent dose from the mouse dose, we would have about 7.6 mg/kg for humans. So, for a 70kg person, you would need about 500mg per day. Whereas, the Mayo clinical trials will be using 20mg/kg, which would be 1400mg per day of fisetin for that same person. <br /><br />I have not been able to ascertain exactly why they do not use the adjusted murine study dosing. But I'm *guessing* that the two day interval is based on the in vitro testing in which they found that senescent cells were killed off in 48 hours. And I'm *guessing* that the higher dose is what they estimate would be required to reach tissue levels in vivo that match those attained in the in vitro experiments.<br /><br />This blog post provides some interesting background information:<br /><br />https://scienceofparkinsons.com/2018/11/10/senolytics/<br /><br />Lou T.https://www.blogger.com/profile/10109091216322863375noreply@blogger.com